Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment

Abhishek, Abhishek; Fuller, Amy; Nakafero, Georgina; Zhang, Weiya; Dumbleton, Jennifer; Hawkey, Christopher; Coupland, Carol; Terkeltaub, Robert; Doherty, Michael

doi:10.1093/rap/rkac086

All Outputs (7)

Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands (2022)
Journal Article
Kamps, A., Runhaar, J., de Ridder, M. A., de Wilde, M., van der Lei, J., Zhang, W., …Bierma-Zeinstra, S. M. (2023). Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands. Osteoarthritis and Cartilage, 31(4), 519-528. https://doi.org/10.1016/j.joca.2022.12.003

Objective To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design A cohort study was conducted using the Integrated P... Read More about Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands.

Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity (2022)
Journal Article
Iwabuchi, S. J., Drabek, M. M., Cottam, W. J., Tadjibaev, A., Mohammadi-Nejad, A. R., Sotiropoulos, S., …Auer, D. P. (2022). Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity. European Journal of Neuroscience, 57(2), 373-387. https://doi.org/10.1111/ejn.15880

The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to inv... Read More about Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia (2022)
Journal Article
Kundakci, B., Hall, M., Atzeni, F., Branco, J. C., Buskila, D., Clauw, D., …Taylor, A. M. (2022). International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia. Seminars in Arthritis and Rheumatism, 57, Article 152101. https://doi.org/10.1016/j.semarthrit.2022.152101

Objectives: To develop evidence-based expert recommendations for non-pharmacological treatments for pain, fatigue, sleep problems, and depression in fibromyalgia. Methods: An international, multidisciplinary Delphi exercise was conducted. Authors of... Read More about International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., …Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls (2022)
Journal Article
Espahbodi, S., Fernandes, G., Hogervorst, E., Thanoon, A., Batt, M., Fuller, C. W., …Zhang, W. (2022). Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls. BMJ Open, 12(4), Article e054371. https://doi.org/10.1136/bmjopen-2021-054371

INTRODUCTION: Professional footballers commonly experience sports-related injury and repetitive microtrauma to the foot and ankle, placing them at risk of subsequent chronic pain and osteoarthritis (OA) of the foot and ankle. Similarly, repeated head... Read More about Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls.

Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain (2022)
Journal Article
Gowler, P. R. W., Turnbull, J., Shahtaheri, M., Gohir, S., Kelly, T., McReynolds, C., …Chapman, V. (2022). Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain. Arthritis and Rheumatology, 74(4), 623-633. https://doi.org/10.1002/art.42000

Objective: Chronic pain due to osteoarthritis (OA) is a major clinical problem, and existing analgesics often have limited beneficial effects and/or adverse effects, necessitating the development of novel therapies. Epoxyeicosatrienoic acids (EETs) a... Read More about Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain.

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment (2022)
Journal Article
Abhishek, A., Fuller, A., Nakafero, G., Zhang, W., Dumbleton, J., Hawkey, C., …Doherty, M. (2022). Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment. Rheumatology Advances in Practice, 6(3), Article rkac086. https://doi.org/10.1093/rap/rkac086

Objective: The aim was to test the feasibility of a randomized controlled trial exploring whether omega-3 fatty acid supplementation limits gout flares during treat-to-target urate-lowering treatment (T2T-ULT). Methods: Adults with at least one gout... Read More about Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment.