In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH

Turpin, Eleanor R.; Taresco, Vincenzo; Al-Hachami, Wathiq A.; Booth, Jonathan; Treacher, Kevin; Tomasi, Simone; Alexander, Cameron; Burley, Jonathan; Laughton, Charles A.; Garnett, Martin C.

doi:10.1021/acs.molpharmaceut.8b00637

All Outputs (2)

Synthesis of methacrylate-terminated block copolymers with reduced transesterification by controlled ring-opening polymerization (2018)
Journal Article

This work presents a robust method to achieve the synthesis of low molecular weight polyesters 26 via ring-opening polymerization (ROP) initiated by 2-hydroxyethyl-methacrylate (HEMA) 27 when using triazabicyclodecene (TBD) as catalyst. The effect th... Read More about Synthesis of methacrylate-terminated block copolymers with reduced transesterification by controlled ring-opening polymerization.

In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH (2018)
Journal Article

© Copyright 2018 American Chemical Society. The problem of predicting small molecule-polymer compatibility is relevant to many areas of chemistry and pharmaceutical science but particularly drug delivery. Computational methods based on Hildebrand and... Read More about In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH.