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All Outputs (59)

Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment (2018)
Journal Article
Chulpanoval, D. S., Kitaeva, K. V., Tazetdinoval, L. G., James, V., Rizvanov, A. A., & Solovyeval, V. V. (2018). Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment. Frontiers in Pharmacology, 9, Article 259. https://doi.org/10.3389/fphar.2018.00259

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circu... Read More about Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment.

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (359-372). Elsevier. https://doi.org/10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ∼146 base pairs of DNA spooled around a dense protein core containing two co... Read More about Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer.

Epigenetic control of microRNA expression and cancer (2017)
Book Chapter
De Brot, S., Rutland, C. S., Mongan, N. P., & James, V. (2018). Epigenetic control of microRNA expression and cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (373-380). Elsevier. https://doi.org/10.1016/B978-0-12-811022-5.00020-6

MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contributi... Read More about Epigenetic control of microRNA expression and cancer.

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., Bates, D. O., Ødum, N., Persson, J. L., & Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), Article R107-R123. https://doi.org/10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More about Regulation of vascular endothelial growth factor in prostate cancer.

Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease (2015)
Journal Article
Inns, J., & James, V. (2015). Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast, 24(4), 364-369. https://doi.org/10.1016/j.breast.2015.04.001

Breast cancer is the second most common malignancy diagnosed in women worldwide. The greatest cause of breast cancer mortality is development of metastasis. For many women metastasis is an early event in breast cancer which goes undetected until its... Read More about Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease.

Autophagy receptor defects and ALS-FTLD (2015)
Journal Article
Majchera, V., Goode, A., James, V., & Layfield, R. (2015). Autophagy receptor defects and ALS-FTLD. Molecular and Cellular Neuroscience, 66(A), 43-52. https://doi.org/10.1016/j.mcn.2015.01.002

Various pathophysiological mechanisms have been implicated in the ALS-FTLD clinicopathological spectrum of neurodegenerative disorders. Here we focus on the role of autophagy, an intracellular catabolic pathway, in these conditions. Growing evidence... Read More about Autophagy receptor defects and ALS-FTLD.

SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians (2012)
Journal Article
Gonzalez-Estevez, C., Felix, D. A., Smith, M. D., Paps, J., Morley, S. J., James, V., Sharp, T. V., & Aboobaker, A. A. (2012). SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genetics, 8(3), Article e1002619. https://doi.org/10.1371/journal.pgen.1002619

Planarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key feature of planarian biology. Here... Read More about SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (2012)
Journal Article
Foxler, D. E., Bridge, K. S., James, V., Webb, T. M., Mee, M., Wong, S. C. K., Feng, Y., Constantin-Teodosiu, D., Petursdottir, T. E., Bjornsson, J., Ingvarsson, S., Ratcliffe, P. J., Longmore, G. D., & Sharp, T. V. (2012). The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nature Cell Biology, 14(2), 201-208. https://doi.org/10.1038/ncb2424

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension1,2. In high O2 tension (normoxia) the PHDs hydroxylate t... Read More about The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ∼80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning (2010)
Journal Article
McGarry, J., Aubeeluck, A., James, V., & Hinsliff-Smith, K. (2011). Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning. Nurse Education in Practice, 11(6), 342-344. https://doi.org/10.1016/j.nepr.2010.11.018

This paper debates the use of problem based learning in accelerated pre-registration nursing programmes that are specifically designed for candidates with ‘graduate status’. We discuss the benefits of using problem based learning (PBL) within a gradu... Read More about Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning.

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma (2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., Lobo, D. N., & Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing (2010)
Journal Article
James, V., Zhang, Y., Foxler, D. E., de Moor, C. H., Kong, Y. W., Webb, T. M., Self, T. J., Feng, Y., Lagos, D., Chu, C.-Y., Rana, T. M., Morley, S. J., Longmore, G. D., Bushell, M., & Sharp, T. V. (2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107(28), 12499-12504. https://doi.org/10.1073/pnas.0914987107

In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action r... Read More about LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension (2006)
Journal Article
Machado, R. D., Aldred, M. A., James, V., Harrison, R. E., Patel, B., Schwalbe, E. C., Gruenig, E., Janssen, B., Koehler, R., Seeger, W., Eickelberg, O., Olschewski, H., Gregory Elliott, C., Glissmeyer, E., Carlquist, J., Kim, M., Torbicki, A., Fijalkowska, A., Szewczyk, G., Parma, J., …Trembath, R. C. (2006). Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension. Human Mutation, 27(2), 121-132. https://doi.org/10.1002/humu.20285

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder is typically sporadic, and in such cases the term idiopathic PAH... Read More about Mutations of the TGF-β type II receptor BMPR2 in pulmonary arterial hypertension.

BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension (2006)
Journal Article
Aldred, M. A., Vijayakrishnan, J., James, V., Soubrier, F., Gomez-Sanchez, M. A., Martensson, G., Galie, N., Manes, A., Corris, P., Simonneau, G., Humbert, M., Morrell, N. W., & Trembath, R. C. (2006). BMPR2 gene rearrangements account for a significant proportion of mutations in familial and idiopathic pulmonary arterial hypertension. Human Mutation, 27(2), 212-213. https://doi.org/10.1002/humu.9398

Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension (2005)
Journal Article
Machado, R. D., James, V., Southwood, M., Harrison, R. E., Atkinson, C., Stewart, S., Morrell, N. W., Trembath, R. C., & Aldred, M. A. (2005). Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension. Circulation, 111(5), 607-613. https://doi.org/10.1161/01.cir.0000154543.07679.08