Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer

Lothion-Roy, Jennifer; Haigh, Daisy B.; Harris, Anna E.; Metzler, Veronika M.; Alsaleem, Mansour; Toss, Michael S.; Kariri, Yousif; Ntekim, Atara; Robinson, Brian D.; Khani, Francesca; Gudas, Lorraine J.; Allegrucci, Cinzia; James, Victoria H.; Madhusudan, Srinivasan; Mather, Melissa; Emes, Richard D.; Archer, Nathan; Fray, Rupert G.; Rakha, Emad; Jeyapalan, Jennie N.; Rutland, Catrin S.; Mongan, Nigel P.; Woodcock, Corinne L.

doi:10.3389/fgene.2022.1096071

All Outputs (4)

Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis (2023)
Journal Article

Extracellular vesicles (EVs) contribute to osteoarthritis pathogenesis through their release into joint tissues and synovial fluid. Synovial fluid-derived EVs have the potential to be direct biomarkers in the causal pathway of disease but also enable... Read More about Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis.

Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis (2023)
Journal Article

Joint tissues release extracellular vesicles (EVs) that potentially sustain joint homeostasis and contribute to osteoarthritis (OA) pathogenesis. EVs are putative novel therapeutics for OA, and transport biologically active molecules (including small... Read More about Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.