Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

Gibson, Claire L.; Srivastava, Kirtiman; Sprigg, Nikola; Bath, Philip M.W.; Bayrakutan, Ulvi

doi:10.1111/jnc.12681

All Outputs (4)

NADPH oxidase mediates TNF-?-evoked in vitro brain barrier dysfunction: roles of apoptosis and time (2014)
Journal Article

The pro-inflammatory cytokine TNF-α severely perturbs the integrity of the blood–brain barrier (BBB). This study explored the specific roles of NADPH oxidase and associated downstream effectors by using human brain microvascular endothelial cells (HB... Read More about NADPH oxidase mediates TNF-?-evoked in vitro brain barrier dysfunction: roles of apoptosis and time.

Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-?I and prooxidant enzyme NADPH oxidase (2014)
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Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase (2014)
Journal Article

Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and mat... Read More about Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase.

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions (2014)
Journal Article

Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation through a series of mechanisms involving Rho-kinase activation. Using an animal model of human focal cerebral ischaemia, this study assessed and confirmed the therapeut... Read More about Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.