Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Foster, Toshana L.; Thompson, Gary S.; Kalverda, Arnout P.; Kankanala, Jayakanth; Bentham, Matthew; Wetherill, Laura F.; Thompson, Joseph; Barker, Amy M.; Clarke, Dean; Noerenberg, Marko; Pearson, Arwen R.; Rowlands, David J.; Homans, Steven W.; Harris, Mark; Foster, Richard; Griffin, Stephen

doi:10.1002/hep.26685

All Outputs (2)

Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function (2013)
Journal Article

Hepatitis C virus (HCV) p7 protein is critical for the efficient production of infectious virions in culture. p7 undergoes genotype-specific protein–protein interactions as well as displaying channel-forming activity, making it unclear whether the ph... Read More about Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release (2013)
Journal Article

Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐targeted drugs licensed in 2012. Many compounds are in the pipeline... Read More about Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.