Skip to main content

Research Repository

Advanced Search

All Outputs (22)

Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning (2023)
Journal Article

In this issue, Griesius et al report that heterozygous Dlg2+/- rats showed a reversal learning impairment on a specific bowl-digging task, whereas other reversal tasks were unaffected. The study suggests that Dlg2 gene disruption, which has been link... Read More about Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning.

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study (2023)
Journal Article

Background Previous studies based on death certificates have found professional soccer players were more likely to die with neurodegenerative diseases, including dementia. Therefore, this study aimed to investigate whether retired professional male... Read More about Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study.

No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain (2023)
Journal Article

Although chronic pain states have been associated with impaired cognitive functions, including memory and cognitive flexibility, the cognitive effects of osteoarthritis (OA) pain remain to be clarified. The aim of this study was to measure cognitive... Read More about No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain.

Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls (2022)
Journal Article

INTRODUCTION: Professional footballers commonly experience sports-related injury and repetitive microtrauma to the foot and ankle, placing them at risk of subsequent chronic pain and osteoarthritis (OA) of the foot and ankle. Similarly, repeated head... Read More about Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls.

The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients (2022)
Journal Article

Previous research has established links between chronic pain and impaired cognitive ability, as well as between chronic pain and anxiety, in osteoarthritis. Furthermore, there is evidence linking risk of osteoarthritis to lower educational attainment... Read More about The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.

Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations (2021)
Journal Article

There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister hooded rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a... Read More about Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations.

Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning (2021)
Journal Article

Spatial memory has been closely related to the medial temporal lobe (MTL) and theta-oscillations are thought to play a key role. However, it remains difficult to investigate MTL activation related to spatial memory with non-invasive electrophysiologi... Read More about Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning.

Frequency? and state?dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anesthetized rats (2020)
Journal Article

Reduced inhibitory GABA function, so‐called neural disinhibition, has been implicated in cognitive disorders, including schizophrenia and age‐related cognitive decline. We previously showed in rats that hippocampal disinhibition by local microinfusio... Read More about Frequency? and state?dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anesthetized rats.

Weniger ist manchmal mehr! (2019)
Journal Article

HIRNFORSCHUNG NEURONALE HEMMUNG Lange Zeit dachten Forscher, dass viele neurologische und psychiatrische Erkrankungen auf einer zu geringen Hirnaktivität beruhen. Doch häufig ist genau das Gegenteil der Fall.

A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences (2018)
Journal Article

Watermaze tests of place learning and memory in rodents, and corresponding reverse translated human paradigms in real or virtual environments, are key tools to study hippocampal function. In common variants, the animal or human participant has to fin... Read More about A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences.

Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation (2015)
Journal Article

© 2015 Wiley Periodicals, Inc. Hippocampal lesions tend to facilitate two-way active avoidance (2WAA) conditioning, where rats learn to cross to the opposite side of a conditioning chamber to avoid a tone-signaled footshock. This classical finding ha... Read More about Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation.