All Outputs (111)

Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study (2016)
Journal Article
Othman, F., Crooks, C. J., & Card, T. R. (2016). Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study. BMJ, 355, Article i5813. https://doi.org/10.1136/bmj.i5813

Objective
To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association.
Design
Cohort study and self controlled case series.
S... Read More about Community acquired pneumonia incidence before and after proton pump inhibitor prescription: population based study.

The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study (2016)
Journal Article
Chu, T. P., Moran, G. W., & Card, T. R. (2016). The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study. Journal of Crohn's and Colitis, 11(5), 578-585. https://doi.org/10.1093/ecco-jcc/jjw192

Background and Aims: Numerous studies have established that mortality risk in IBD patients is higher than the general population, but the causes of death have seldom been examined. We aimed to describe causes of death in IBD.

Methods: A matched co... Read More about The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study.

Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England (2016)
Journal Article
England. British Journal of Cancer, 115(7), https://doi.org/10.1038/bjc.2016.250

Background: More than 20% of colorectal cancers are diagnosed following an emergency presentation. We aimed to examine pre-diagnostic primary care consultations and related symptoms comparing patients diagnosed as emergencies with those diagnosed thr... Read More about Do colorectal cancer patients diagnosed as an emergency differ from non-emergency patients in their consultation patterns and symptoms?: a longitudinal data-linkage study in England.

Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study (2016)
Journal Article
Ratib, S., Walker, A. J., Card, T. R., & Grainge, M. J. (2016). Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study. Journal of Hematology and Oncology, 9, Article 60. https://doi.org/10.1186/s13045-016-0291-0

Background: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported.
Methods: We condu... Read More about Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study.

Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England (2016)
Journal Article
Abdul Sultan, A., West, J., Ban, L., Humes, D., Tata, L. J., Fleming, K. M., Nelson-Piercy, C., & Card, T. R. (2016). Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England. Inflammatory Bowel Diseases, 22(7), 1621-1630. https://doi.org/10.1097/MIB.0000000000000802

Background: There is limited contemporary population based evidence on adverse birth outcomes and pregnancy related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variatio... Read More about Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England.

Proton pump inhibitor prescribing patterns in the UK: a primary care database study (2016)
Journal Article
Othman, F., Card, T. R., & Crooks, C. J. (2016). Proton pump inhibitor prescribing patterns in the UK: a primary care database study. Pharmacoepidemiology and Drug Safety, 25(9), 1079-1087. https://doi.org/10.1002/pds.4043

Purpose: To determine the prevalence and pattern of proton pump inhibitor (PPI) prescription and the practices employed to reduce PPI use in the UK general population.

Methods: The UK's Clinical Practice Research Database was used to identify indi... Read More about Proton pump inhibitor prescribing patterns in the UK: a primary care database study.

Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data (2016)
Journal Article
Walker, A. J., Baldwin, D. R., Card, T. R., Powell, H. A., Hubbard, R. B., & Grainge, M. J. (in press). Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data. British Journal of Cancer, 115(1), https://doi.org/10.1038/bjc.2016.143

Background: Venous thromboembolism is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high risk periods may provide the opportunity for better targeted intervention.

Methods: We conduc... Read More about Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data.

Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported (2016)
Journal Article
Card, T. R., Langan, S. M., & Chu, T. P. (2016). Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported. Digestive Diseases and Sciences, 61(9), 2619-2626. https://doi.org/10.1007/s10620-016-4195-1

Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited num... Read More about Extra-gastrointestinal manifestations of inflammatory bowel disease may be less common than previously reported.

When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data (2015)
Journal Article
Walker, A. J., West, J., Card, T. R., Crooks, C. J., Kirwan, C. C., & Grainge, M. J. (2015). When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data. Blood, 127(7), 849-857. https://doi.org/10.1182/blood-2015-01-625582

Breast cancer patients are at increased risk of VTE, particularly in the peri-diagnosis period. However, no previous epidemiological studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to det... Read More about When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data.

Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment (2015)
Journal Article
Canavan, C., West, J., & Card, T. R. (in press). Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment. PharmacoEconomics, 34(2), https://doi.org/10.1007/s40273-015-0339-y

INTRODUCTION: Health economic models are increasingly important in funding decisions but most are based on data, which may therefore not represent the general population. We sought to establish the potential of real-world data available within the Cl... Read More about Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment.

Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study (2015)
Journal Article
Canavan, C., West, J., & Card, T. R. (2015). Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study. PLoS ONE, 10(10), Article e0139389. https://doi.org/10.1371/journal.pone.0139389

BACKGROUND: Irritable bowel syndrome (IBS), a chronic functional condition, considerably reduces quality of life (QoL) and referral to gastroenterology is common. Until now, however, the impact of seeing a gastroenterologist for IBS on patients’ QoL... Read More about Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study.

Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study (2015)
Journal Article
Ban, L., Tata, L. J., Humes, D., Fiaschi, L., & Card, T. R. (2015). Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study. Alimentary Pharmacology and Therapeutics, 42(7), https://doi.org/10.1111/apt.13354

Background: Clinical studies have reported reduced fertility in women with inflammatory bowel disease (IBD).

Aim: To compare fertility rates in women with IBD to those in women without IBD and assess whether the relative fertility differed followi... Read More about Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study.

Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis (2015)
Journal Article
Abdul Sultan, A., Crooks, C. J., Card, T. R., Tata, L. J., Fleming, K. M., & West, J. (2015). Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut, 64(8), https://doi.org/10.1136/gutjnl-2014-308285

INTRODUCTION: Quantifying excess cause-specific mortality among people with coeliac disease (CD) compared with the general population accounting for competing risks will allow accurate information to be given on risk of death from specific causes.... Read More about Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis.

Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography (2015)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Jelpke, M., Ottey, D. S., Wilkes, E. A., Card, T. R., Aithal, G. P., & Guha, I. N. (2015). Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography. BMJ Open, 5(4), Article e007516. https://doi.org/10.1136/bmjopen-2014-007516

OBJECTIVES: To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting.

DESIGN: Prospective cross-sectional study.

SETTING: Two primary care practices (adult... Read More about Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography.

Socioeconomic variation in the incidence of childhood coeliac disease in the UK (2015)
Journal Article
Zingone, F., West, J., Crooks, C. J., Fleming, K. M., Card, T. R., Ciacci,, C., & Tata, L. J. (2015). Socioeconomic variation in the incidence of childhood coeliac disease in the UK. Archives of Disease in Childhood, 100(5), https://doi.org/10.1136/archdischild-2014-307105

BACKGROUND: Serological studies indicate that evidence of coeliac disease (CD) exists in about 1% of all children, but we lack estimates of current diagnostic patterns among children and how they vary by socioeconomic group.

METHODS: We identifie... Read More about Socioeconomic variation in the incidence of childhood coeliac disease in the UK.

Screening for celiac disease in the general population and in high-risk groups (2014)
Journal Article
Ludvigsson, J. F., Card, T. R., Kaukinen, K., Bai, J., Zingone, F., Sanders, D. S., & Murray, J. A. (in press). Screening for celiac disease in the general population and in high-risk groups. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640614561668

BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death.

OBJECTIVES: To review the liter... Read More about Screening for celiac disease in the general population and in high-risk groups.

Psychological morbidity of celiac disease: a review of the literature (2014)
Journal Article
Zingone, F., Swift, G. L., Card, T. R., Sanders, D. S., Ludvigsson, J. F., & Bai, J. C. (2015). Psychological morbidity of celiac disease: a review of the literature. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640614560786

BACKGROUND: Celiac disease has been linked to decreased quality of life and certain mood disorders. The effect of the gluten free diet on these psychological aspects of the disease is still unclear.

OBJECTIVES: The objective of this article is to... Read More about Psychological morbidity of celiac disease: a review of the literature.

Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database (2014)
Journal Article
Card, T. R., Siffledeen, J., & Fleming, K. M. (2014). Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database. United European Gastroenterology Journal, 2(6), https://doi.org/10.1177/2050640614554217

Background: Inflammatory bowel disease (IBD) patients are sometimes first diagnosed with irritable bowel syndrome (IBS), which may be construed as a misdiagnosis.

Objective: The objective of this article is to determine if this occurs more than ex... Read More about Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome?: report of a case-control study in the General Practice Research Database.

The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study (2014)
Journal Article
Canavan, C., Card, T. R., & West, J. (2014). The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study. PLoS ONE, 9(9), Article e106478. https://doi.org/10.1371/journal.pone.0106478

BACKGROUND: Guidelines recommend Irritable Bowel Syndrome (IBS) diagnosis and management in primary care with minimal investigations; however little evidence exists regarding risk of organic gastrointestinal conditions following diagnosis of IBS and... Read More about The incidence of other gastroenterological disease following diagnosis of irritable bowel syndrome in the UK: a cohort study.

Review article: the economic impact of the irritable bowel syndrome (2014)
Journal Article
Canavan, C., West, J., & Card, T. R. (in press). Review article: the economic impact of the irritable bowel syndrome. Alimentary Pharmacology and Therapeutics, 40(9), https://doi.org/10.1111/apt.12938

Background: Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal system affecting a large number of people worldwide. Whilst it has no attributable mortality, it has substantial impact on patients' quality of life (... Read More about Review article: the economic impact of the irritable bowel syndrome.