Skip to main content

Research Repository

Advanced Search

Screening for celiac disease in the general population and in high-risk groups

Ludvigsson, Jonas F.; Card, Timothy R.; Kaukinen, Katri; Bai, Julio; Zingone, Fabiana; Sanders, David S.; Murray, Joseph A.

Authors

Jonas F. Ludvigsson

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

Katri Kaukinen

Julio Bai

Fabiana Zingone

David S. Sanders

Joseph A. Murray



Abstract

BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death.

OBJECTIVES: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening.

METHODS: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail.

RESULTS: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective.

CONCLUSIONS: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

Journal Article Type Article
Journal United European Gastroenterology Journal
Print ISSN 2050-6406
Electronic ISSN 2050-6414
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
APA6 Citation Ludvigsson, J. F., Card, T. R., Kaukinen, K., Bai, J., Zingone, F., Sanders, D. S., & Murray, J. A. (in press). Screening for celiac disease in the general population and in high-risk groups. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640614561668
DOI https://doi.org/10.1177/2050640614561668
Keywords Celiac disease, gluten, gluten-free diet, review, screening, prevention, risk, quality of life, World Health Organization
Publisher URL http://ueg.sagepub.com/content/3/2/106
Related Public URLs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406899/
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

Files

CD_screening_Oct14_2014.pdf (661 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations

;