Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration

Negm, Ola H.; MacKenzie, B.; Hamed, M.R.; Ahmad, O.A.J.; Shone, Clifford C.; Humphreys, D.P.; Acharya, K. Ravi; Loscher, Christine E.; Marszalowska, Izabela; Lynch, Mark; Wilcox, Mark H.; Monaghan, Tanya M.

doi:10.1111/cei.12946

All Outputs (3)

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection (2018)
Journal Article

We provide a detailed overview of a novel high-throughput protein microarray assay for the determination of anti-C. difficile antibody levels in human sera and in separate preparations of polyclonal IVIg. The protocol describes the methodological ste... Read More about A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection.

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection (2017)
Journal Article

Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.... Read More about High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration (2017)
Journal Article

The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recur... Read More about Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.