All Outputs (5)

Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods (2021)
Journal Article
Lu, Y., Joosten, L., Donkers, J., Andriulo, F., Slaghek, T. M., Phillips-Jones, M. K., …Harding, S. E. (2021). Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods. Scientific Reports, 11(1), 1-12. https://doi.org/10.1038/s41598-021-93424-0

Lignins are valuable renewable resources for the potential production of a large array of biofuels, aromatic chemicals and biopolymers. Yet native and industrial lignins are complex, highly branched and heterogenous macromolecules, properties that ha... Read More about Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods.

Quantifying the concentration dependence of sedimentation coefficients for globular macromolecules: a continuing age-old problem (2021)
Journal Article
Winzor, D. J., Dinu, V., Scott, D. J., & Harding, S. E. (2021). Quantifying the concentration dependence of sedimentation coefficients for globular macromolecules: a continuing age-old problem. Biophysical Reviews, 13(2), 273-288. https://doi.org/10.1007/s12551-021-00793-x

This retrospective investigation has established that the early theoretical attempts to directly incorporate the consequences of radial dilution into expressions for variation of the sedimentation coefficient as a function of the loading concentratio... Read More about Quantifying the concentration dependence of sedimentation coefficients for globular macromolecules: a continuing age-old problem.

Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant (2021)
Journal Article
Cutajar, M., Andriulo, F., Thomsett, M. R., Moore, J. C., Couturaud, B., Howdle, S. M., …Harding, S. E. (2021). Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant. Scientific Reports, 11(1), Article 7343. https://doi.org/10.1038/s41598-021-86543-1

There is currently a pressing need for the development of novel bioinspired consolidants for waterlogged, archaeological wood. Bioinspired materials possess many advantages, such as biocompatibility and sustainability, which makes them ideal to use i... Read More about Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant.

Glycoconjugate vaccines against Salmonella enterica serovars and Shigella species: existing and emerging methods for their analysis (2021)
Journal Article
Bazhenova, A., Gao, F., Bolgiano, B., & Harding, S. E. (2021). Glycoconjugate vaccines against Salmonella enterica serovars and Shigella species: existing and emerging methods for their analysis. Biophysical Reviews, 13(2), 221-246. https://doi.org/10.1007/s12551-021-00791-z

The global spread of enteric disease, the increasingly limited options for antimicrobial treatment and the need for effective eradication programs have resulted in an increased demand for glycoconjugate enteric vaccines, made with carbohydrate-based... Read More about Glycoconjugate vaccines against Salmonella enterica serovars and Shigella species: existing and emerging methods for their analysis.

Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques (2021)
Journal Article
Gillis, R. B., Solomon, H. V., Govada, L., Oldham, N. J., Dinu, V., Jiwani, S. I., …Adams, G. G. (2021). Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques. Scientific Reports, 11(1), Article 1737. https://doi.org/10.1038/s41598-021-81251-2

© 2021, The Author(s). This study concerns glulisine, a rapid-acting insulin analogue that plays a fundamental role in diabetes management. We have applied a combination of methods namely X-ray crystallography, and biophysical characterisation to pro... Read More about Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques.