All Outputs (4)

Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1 (2024)
Journal Article
Coleman, D. J., Keane, P., Chin, P. S., Ames, L., Kellaway, S., Blair, H., …Bonifer, C. (2024). Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1. iScience, 27(4), Article 109576. https://doi.org/10.1016/j.isci.2024.109576

AML is characterized by mutations in genes associated with growth regulation such as internal tandem duplications (ITD) in the receptor kinase FLT3. Inhibitors targeting FLT3 (FLT3i) are being used to treat patients with FLT3-ITD+ but most relapse an... Read More about Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1.

Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth (2024)
Journal Article
Kellaway, S. G., Potluri, S., Keane, P., Blair, H. J., Ames, L., Worker, A., …Bonifer, C. (2024). Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth. Nature Communications, 15(1), Article 1359. https://doi.org/10.1038/s41467-024-45691-4

Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating blast cel... Read More about Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth.

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis (2024)
Journal Article
Potluri, S., Kellaway, S. G., Coleman, D. J. L., Keane, P., Imperato, M. R., Assi, S. A., …Bonifer, C. (2024). Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis. Leukemia, 38(2), 403–407. https://doi.org/10.1038/s41375-023-02118-1

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth (2023)
Journal Article
Coleman, D. J., Keane, P., Luque-Martin, R., Chin, P. S., Blair, H., Ames, L., …Bonifer, C. (2023). Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth. Cell Reports, 42(12), Article 113568. https://doi.org/10.1016/j.celrep.2023.113568

Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multiple gene... Read More about Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth.