Research Repository

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Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, doi:10.1002/lio2.168. ISSN 2378-8038

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), doi:10.3892/ol.2018.8837. ISSN 1792-1074

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More

Pulmonary basaloid squamous cell carcinoma in a dog (2018)
Journal Article
Morey-Matamalas, A., de Stefani, A., Corbetta, D., Grau-Roma, L., & de Brot, S. (2018). Pulmonary basaloid squamous cell carcinoma in a dog. Journal of Comparative Pathology, 159, doi:10.1016/j.jcpa.2017.12.007. ISSN 0021-9975

A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, the left kidney and the c... Read More

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics (2017)
Journal Article
Simpson, S., Dunning, M. D., de Brot, S., Grau-Roma, L., Mongan, N. P., & Rutland, C. S. (2017). Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics. Acta Veterinaria Scandinavica, 59, doi:10.1186/s13028-017-0341-9. ISSN 1751-0147

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, o... Read More

Epigenetic control of microRNA expression and cancer (2017)
Book Chapter
De Brot, S., Rutland, C. S., Mongan, N. P., & James, V. (2018). Epigenetic control of microRNA expression and cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs, 373-380. Elsevier. doi:10.1016/B978-0-12-811022-5.00020-6

MicroRNAs (miRNAs or miRs) are involved in pathways central to homeostasis and cellular function, including proliferation, differentiation, and apoptosis; processes which when aberrantly regulated contribute to the hallmarks of cancer. The contributi... Read More

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs, 359-372. Elsevier. doi:10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ∼146 base pairs of DNA spooled around a dense protein core containing two co... Read More

Pathology in practice: hereditary nephropathy in an English Cocker Spaniel (2017)
Journal Article
de Brot, S., Adamany, J., Baiker, K., Allegrucci, C., Polledo, L., & Grau-Roma, L. (2017). Pathology in practice: hereditary nephropathy in an English Cocker Spaniel. Journal of the American Veterinary Medical Association, 251(6), (661-664). doi:10.2460/javma.251.6.661. ISSN 0003-1488

A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kid... Read More

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. doi:10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More

Quadrilateral suspensory and straight sesamoidean ligament calcifying desmopathy in an Arabian mare (2016)
Journal Article
Hui, S., Turner, S., Leaman, T., de Brot, S., & Barakzai, S. (2016). Quadrilateral suspensory and straight sesamoidean ligament calcifying desmopathy in an Arabian mare. Equine Veterinary Education, doi:10.1111/eve.12705. ISSN 0957-7734

A 5-year-old Arabian mare was referred for the investigation of recent behavioural change, generalised stiffness, and owner-reported polyuria and polydipsia. Clinical examination revealed severe pain associated with palpation along the entire length... Read More

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Gardner, D. S., de Brot, S., Dunford, L. J., Grau-Roma, L., Welham, S. J., Fallman, R., …Devonald, M. A. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310, doi:10.1152/ajprenal.00389.2015. ISSN 1931-857X

Background: Acute Kidney Injury (AKI) is a common and serious disease with no specific treatment. An episode of AKI may affect organs distant to the kidney, further increasing the morbidity associated with AKI. The mechanism of organ cross-talk after... Read More

Wooden breast lesions in broiler chickens in the UK (2016)
Journal Article
de Brot, S., Perez, S., Shivaprasad, H., Baiker, K., Polledo, L., Clark, M., & Grau-Roma, L. (2016). Wooden breast lesions in broiler chickens in the UK. Veterinary Record, 178(6), doi:10.1136/vr.103561. ISSN 0042-4900

A new condition causing significant economic losses due to lesions in the pectoralis major muscle of commercial broiler chickens has been recently reported in Finland. The condition has been named wooden breast and is characterized by its gross and h... Read More

Sequence and partial functional analysis of canine Bcl-2 family proteins (2015)
Journal Article
de Brot, S., Schade, B., Croci, M., Dettwiler, M., & Guscetti, F. (2016). Sequence and partial functional analysis of canine Bcl-2 family proteins. Research in Veterinary Science, 104, doi:10.1016/j.rvsc.2015.12.001. ISSN 0034-5288

Dogs present with spontaneous neoplasms biologically similar to human cancers. Apoptotic pathways are deregulated during cancer genesis and progression and are important for therapy. We have assessed the degree of conservation of a set of canine Bcl-... Read More

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), doi:10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More

Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome (2015)
Journal Article
Monthoux, C., de Brot, S., Jackson, M., Bleul, U., & Walter, J. (2015). Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC Veterinary Research, 11(12), doi:10.1186/s12917-015-0318-8. ISSN 1746-6148

BACKGROUND: Skin malformations that resembled manifestations of Ehlers-Danlos-Syndrome were described in a variety of domestic animals during the last century as cutis hyperelastica, hyperelastosis cutis, dermatosparaxis, dermal/collagen dysplasia... Read More