All Outputs (41)

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.

Method for RNA extraction and transcriptomic analysis of single fungal spores (2019)
Journal Article

Transcriptomic analysis of single cells has been increasingly in demand in recent years, thanks to technological and methodological advances as well as growing recognition of the importance of individuals in biological systems. However, the majority... Read More about Method for RNA extraction and transcriptomic analysis of single fungal spores.

Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments (2019)
Journal Article

A bis-epoxide monomer was synthesised in two steps from (R)-carvone, a terpenoid renewable feedstock derived from spearmint oil, and used to prepare ?-aminoalcohol oligomers in polyaddition reactions with bis-amines without requiring solvent or catal... Read More about Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments.

Extreme osmotolerance and halotolerance in food-relevant yeasts and the role of glycerol-dependent cell individuality (2019)
Journal Article

Osmotolerance and halotolerance are used to describe resistance to sugars and salt, respectively. Here, a comprehensive screen of more than 600 different yeast isolates revealed that osmosensitive species were equally affected by NaCl and glucose. Ho... Read More about Extreme osmotolerance and halotolerance in food-relevant yeasts and the role of glycerol-dependent cell individuality.

Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens (2018)
Journal Article

A range of fungicides or antifungals are currently deployed to control fungi in agriculture or medicine, but resistance to current agents is growing so new approaches and molecular targets are urgently needed. Recently, different aminoglycoside antib... Read More about Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens.

Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials (2018)
Journal Article

Antimalarial drug resistance hampers effective malaria treatment. Critical SNPs in a particular, putative amino acid transporter were recently linked to chloroquine (CQ) resistance in malaria parasites. Here, we show that this conserved protein (PF3D... Read More about Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials.

Mitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess (2017)
Journal Article

The essential micronutrient copper is tightly regulated in organisms, as environmental exposure or homeostasis defects can cause toxicity and neurodegenerative disease. The principal target(s) of copper toxicity have not been pinpointed, but one key... Read More about Mitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess.

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials (2017)
Journal Article

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the MMV Malaria Box... Read More about The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials.

The next generation fungal diversity researcher (2017)
Journal Article

Fungi are more important to our lives than is assumed by the general public. They can comprise both devastating pathogens and plant-associated mutualists in nature, and several species have also become important workhorses of biotechnology. Fungal di... Read More about The next generation fungal diversity researcher.

Metal-based combinations that target protein synthesis by fungi (2017)
Journal Article

A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent nee... Read More about Metal-based combinations that target protein synthesis by fungi.

Phenotypic heterogeneity in fungi: Importance and methodology (2016)
Journal Article

Phenotypic heterogeneity describes the variation that exists between individual cells, spores or other biological entities within genetically-uniform populations of fungi or other organisms. Studies over the last 10–-15 years have successfully used l... Read More about Phenotypic heterogeneity in fungi: Importance and methodology.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016)
Journal Article

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More about Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth (2015)
Journal Article

Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Yet its... Read More about The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth.

Novel, synergistic antifungal combinations that target translation fidelity (2015)
Journal Article

There is an unmet need for new antifungal or fungicide treatments, as resistance to existing treatments grows. Combination treatments help to combat resistance. Here we develop a novel, effective target for combination antifungal therapy. Different a... Read More about Novel, synergistic antifungal combinations that target translation fidelity.

Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h) (2014)
Journal Article

The authors would like to add an additional acknowledgement as follows: We wish to acknowledge Fikry Abushofa for technical assistance.

Genes involved in the induction of liver growth by peroxisome proliferators (2014)
Journal Article

The mechanisms regulating the induction of hepatic DNA synthesis by PPARα agonists are currently incompletely understood, and we set out to determine whether there are different mechanisms of induction for PPARα agonists and other hepatic growth agen... Read More about Genes involved in the induction of liver growth by peroxisome proliferators.

Population heterogeneity and dynamics in starter culture and lag phase adaptation of the spoilage yeast Zygosaccharomyces bailii to weak acid preservatives (2014)
Journal Article

The food spoilage yeast Zygosaccharomyces bailii shows great resistance to weak-acid preservatives, including sorbic acid (2, 4-hexadienoic acid). That extreme resistance was shown to be due to population heterogeneity, with a small sub-population of... Read More about Population heterogeneity and dynamics in starter culture and lag phase adaptation of the spoilage yeast Zygosaccharomyces bailii to weak acid preservatives.

The antimalarial drug quinine interferes with serotonin biosynthesis and action (2014)
Journal Article

The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As... Read More about The antimalarial drug quinine interferes with serotonin biosynthesis and action.

Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress (2013)
Journal Article

Populations of genetically uniform microorganisms exhibit phenotypic heterogeneity, where individual cells have varying phenotypes. Such phenotypes include fitness-determining traits. Phenotypic heterogeneity has been linked to increased population-l... Read More about Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress.

Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine (2013)
Journal Article

Chloroquine (CQ) has been a mainstay of antimalarial drug treatment for several decades. Additional therapeutic actions of CQ have been described, including some reports of fungal inhibition. Here we investigated the action of CQ in fungi, including... Read More about Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine.