All Outputs (4)

Mitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess (2017)
Journal Article

The essential micronutrient copper is tightly regulated in organisms, as environmental exposure or homeostasis defects can cause toxicity and neurodegenerative disease. The principal target(s) of copper toxicity have not been pinpointed, but one key... Read More about Mitochondrial Ferredoxin Determines Vulnerability of Cells to Copper Excess.

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials (2017)
Journal Article

To cope with growing resistance to current antimalarials, new drugs with novel modes of action are urgently needed. Molecules targeting protein synthesis appear to be promising candidates. We identified a compound (MMV665909) from the MMV Malaria Box... Read More about The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials.

The next generation fungal diversity researcher (2017)
Journal Article

Fungi are more important to our lives than is assumed by the general public. They can comprise both devastating pathogens and plant-associated mutualists in nature, and several species have also become important workhorses of biotechnology. Fungal di... Read More about The next generation fungal diversity researcher.

Metal-based combinations that target protein synthesis by fungi (2017)
Journal Article

A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent nee... Read More about Metal-based combinations that target protein synthesis by fungi.