Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials

Tindall, Sarah M.; Valli�res, Cindy; Lakhani, Dev H.; Islahudin, Farida; Ting, Kang-Nee; Avery, Simon V.

doi:10.1038/s41598-018-20816-0

All Outputs (2)

Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens (2018)
Journal Article

A range of fungicides or antifungals are currently deployed to control fungi in agriculture or medicine, but resistance to current agents is growing so new approaches and molecular targets are urgently needed. Recently, different aminoglycoside antib... Read More about Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens.

Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials (2018)
Journal Article

Antimalarial drug resistance hampers effective malaria treatment. Critical SNPs in a particular, putative amino acid transporter were recently linked to chloroquine (CQ) resistance in malaria parasites. Here, we show that this conserved protein (PF3D... Read More about Heterologous expression of a novel drug transporter from the malaria parasite alters resistance to quinoline antimalarials.