Novelty and Convergence in Adaptation to Whole Genome Duplication

Bohut�nsk�, Magdalena; Alston, Mark; Monnahan, Patrick; Mand�kov�, Terezie; Bray, Sian; Paajanen, Pirita; Kol�?, Filip; Yant, Levi

doi:10.1093/molbev/msab096

All Outputs (5)

On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next? (2023)
Journal Article

Identifying the association between phenotypes and genotypes is the fundamental basis of genetic analyses. Although genomic technologies used to generate data have rapidly advanced within the last 20 years, the statistical models used in genome-wide... Read More about On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next?.

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

Analysis of phenotype-genotype associations using genomic informational field theory (GIFT) (2022)
Journal Article

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we... Read More about Analysis of phenotype-genotype associations using genomic informational field theory (GIFT).

Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles (2021)
Journal Article

Relative contributions of pre-existing vs de novo genomic variation to adaptation are poorly understood, especially in polyploid organisms. We assess this in high resolution using autotetraploid Arabidopsis arenosa, which repeatedly adapted to toxic... Read More about Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles.

Novelty and Convergence in Adaptation to Whole Genome Duplication (2021)
Journal Article

Whole genome duplication (WGD) can promote adaptation but is disruptive to conserved processes, especially meiosis. Studies in Arabidopsis arenosa revealed a coordinated evolutionary response to WGD involving interacting proteins controlling meiotic... Read More about Novelty and Convergence in Adaptation to Whole Genome Duplication.