All Outputs (11)

Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies (2021)
Journal Article

Background: Fatigue is the inability to achieve or maintain an expected work output resulting from central or peripheral mechanisms. The prevalence of inflammatory bowel disease (IBD) fatigue can reach 86% in active disease, persisting in 50%-52% of... Read More about Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies.

STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction (2020)
Journal Article

© 2020 American Association for Cancer Research. Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphologic changes in response to brain metastasis... Read More about STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction.

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI (2018)
Journal Article

Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies with several early-phase clinical trials in progress including early repo... Read More about 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI (2017)
Journal Article

© The Author(s) 2017. Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-... Read More about Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI.

Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis (2016)
Journal Article

Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1R132H in the subventricular zone (SVZ) of the adult... Read More about Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis.

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development (2016)
Journal Article

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maint... Read More about SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

ASPP2 controls epithelial plasticity and inhibits metastasis through ?-catenin-dependent regulationofZEB1 (2014)
Journal Article

T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS (2014)
Journal Article

Neuroinflammation has been identified as a potential therapeutic target in amyotrophic lateral sclerosis (ALS), but relevant biomarkers are needed. The superoxide dismutase (SOD1)G93A transgenic mouse model of ALS offers a unique opportunity to study... Read More about T(2)-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker (2014)
Journal Article

Metastatic spread of cancer cells to the brain is associated with high mortality, primarily because current diagnostic tools identify only well-advanced metastases. Brain metastases have been shown to induce a robust glial response, including both as... Read More about Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker.

Functional role of endothelial adhesion molecules in the early stages of brain metastasis (2013)
Journal Article

Structural and functional effects of metastases in rat brain determined by multimodal MRI (2013)
Journal Article

Metastasis to the brain results in significant impairment of brain function and poor patient survival. Currently, magnetic resonance imaging (MRI) is under‐utilised in monitoring brain metastases and their effects on brain function. Here, we sought t... Read More about Structural and functional effects of metastases in rat brain determined by multimodal MRI.