All Outputs (14)

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy (2020)
Journal Article
Townley, A., & Wheatley, S. P. (2020). Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. Journal of Cell Science, 133(21), Article jcs247379. https://doi.org/10.1242/jcs.247379

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy.

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. (2020)
Other
Wheatley, S., & Townley, A. R. Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy..

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission (2020)
Journal Article
Le Roch, K. G., Holder, A. A., Bottrill, A. R., Stanway, R. R., Wall, R. J., Tewari, R., …Brady, D. (2020). Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell Reports, 30(6), 1883-1897.e6. https://doi.org/10.1016/j.celrep.2020.01.033

Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine... Read More about Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis (2019)
Journal Article
Capalbo, L., Bassi, Z. I., Geymonat, M., Todesca, S., Copoiu, L., Enright, A. J., …D’Avino, P. P. (2019). The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Nature Communications, 10(1), Article 4513. https://doi.org/10.1038/s41467-019-12507-9

The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue organization, and cili... Read More about The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.

Transporting cells over several days without dry-ice (2019)
Journal Article
Wheatley, S. P., & Wheatley, D. N. (2019). Transporting cells over several days without dry-ice. Journal of Cell Science, 132(21), jcs238139. https://doi.org/10.1242/jcs.238139

This paper describes a simple, hazard-free and inexpensive procedure that allows researchers to send cultured cells across the globe at ambient temperatures. The method enables transit of up to 2 weeks without compromising cell recovery. Its use will... Read More about Transporting cells over several days without dry-ice.

Survivin at a glance (2019)
Journal Article
Wheatley, S. P., & Altieri, D. C. (2019). Survivin at a glance. Journal of Cell Science, 132(7), Article jcs223826. https://doi.org/10.1242/jcs.223826

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all can... Read More about Survivin at a glance.

Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3 (2018)
Journal Article
Humphry, N. J., & Wheatley, S. P. (2018). Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3. Biology Open, 7(10), 037374. https://doi.org/10.1242/bio.037374

Survivin expression is pivotal to life and death at the cellular level. For
the past decade its pro-survival activity has been attributed to its
essential role in cell proliferation and its ability to inhibit apoptosis.
However, a growing body of... Read More about Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3.

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis (2018)
Journal Article
Wall, R. J., Ferguson, D. J. P., Freville, A., Franke-Fayard, B., Brady, D., Zeeshan, M., Bottrill, A. R., Wheatley, S., Fry, A. M., Janse, C. J., Yamano, H., Holder, A. A., Guttery, D. S., & Tewari, R. (in press). Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Scientific Reports, 8(1), Article 5610. https://doi.org/10.1038/s41598-018-23871-9

The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contributes to... Read More about Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator (2016)
Journal Article
Dunajova, L., Cash, E., Markus, R., Rochette, S., Townley, A. R., & Wheatley, S. P. (in press). The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator. Journal of Cell Science, 129, https://doi.org/10.1242/jcs.183277

Survivin is a cancer-associated protein that exists in several locations in the cell. Its cytoplasmic residence in interphase cells is governed by CRM1-mediated nuclear exportation, and its localisation during mitosis to the centromeres and midzone m... Read More about The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator.

Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes (2015)
Journal Article
Roques, M., Wall, R. J., Douglass, A. P., Ramaprasad, A., Ferguson, D. J. P., Kaindama, M. L., …Tewari, R. (2015). Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes. PLoS Pathogens, 11(11), Article e1005273. https://doi.org/10.1371/journal.ppat.1005273

Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi... Read More about Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes.

Mitotic activity of survivin is regulated by acetylation at K129 (2015)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (2015). Mitotic activity of survivin is regulated by acetylation at K129. Cell Cycle, 14(11), https://doi.org/10.1080/15384101.2015.1033597

Survivin is a cancer-associated protein regulated by multiple factors, including acetylation at K129 within its C-terminal alpha-helical tail. Acetylation of survivin is being pursued as a potential prognostic marker in breast cancer. This modificat... Read More about Mitotic activity of survivin is regulated by acetylation at K129.

The functional repertoire of survivin's tails (2015)
Journal Article
Wheatley, S. P. (2015). The functional repertoire of survivin's tails. Cell Cycle, 14(2), https://doi.org/10.4161/15384101.2014.979680

Survivin is a multitasking protein that can inhibit cell death and that is essential for mitosis. Due to these prosurvival activities and the correlation of its expression with tumour resistance to conventional cancer treatments, survivin has receive... Read More about The functional repertoire of survivin's tails.

Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer (2014)
Journal Article
Aljaberi, A. M., Webster, J. R., & Wheatley, S. P. (in press). Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell International, 14, Article 78. https://doi.org/10.1186/s12935-014-0078-8

Background
Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essentia... Read More about Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.

Nuclear survivin: cellular consequences and therapeutic implications (2011)
Book Chapter
Wheatley, S. P. (2011). Nuclear survivin: cellular consequences and therapeutic implications. In H. Gali-Muhtasib (Ed.), Advances in cancer therapy. InTech. https://doi.org/10.5772/24795

The great deluge algorithm explores neighbouring solutions which are accepted if they are better than the best solution so far or if the detriment in quality is no larger than the current water level. In the original great deluge method, the water le... Read More about Nuclear survivin: cellular consequences and therapeutic implications.