Skip to main content

Research Repository

Advanced Search

All Outputs (116)

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis (2020)
Journal Article
Meng, D., Welton, T., Elsarraj, A., Morgan, P. S., das Nair, R., Constantinescu, C. S., …Dineen, R. A. (2020). Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis. Human Brain Mapping, 42(2), 495-509. https://doi.org/10.1002/hbm.25239

Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the... Read More about Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., …Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics.

We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews (2020)
Journal Article
Topcu, G., Griffiths, H., Bale, C., Trigg, E., Clarke, S., Potter, K.-J., …das Nair, R. (2020). Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews. Clinical Psychology Review, 82, Article 101923. https://doi.org/10.1016/j.cpr.2020.101923

This meta-review aimed to synthesise evidence on psychosocial adjustment to multiple sclerosis, to identify available treatment models and services for recently diagnosed individuals, and to explore their effectiveness. MEDLINE, CINAHL, EMBASE, PsycI... Read More about Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article
Hall, M., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol. BMJ Open, 10(9), Article e037760. https://doi.org/10.1136/bmjopen-2020-037760

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis (2020)
Journal Article
Kneebone, I. I., Fife-Schaw, C., Lam, L. T., & das Nair, R. (2020). The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis. F1000Research, 9, Article 1038. https://doi.org/10.12688/f1000research.25129.1

Background: Depression is common in multiple sclerosis (MS); however, its assessment is complicated by biological processes. In this context it is important to consider the performance of depression screening measures including that their factor stru... Read More about The factor structure of the Center for Epidemiological Study - Depression Scale in people with multiple sclerosis.

Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., Nair, R. D., Jones, A., Jones, F., …Thomas, S. (2020). Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study. British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction: Post-stroke fatigue (PSF) is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning: it is also associated with poor outcomes and increased mortality.... Read More about Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study.

Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., …Thomas, S. (2020). Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2). British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction

Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and increased mortality. The... Read More about Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2).

Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke (2020)
Journal Article
Geraghty, J., Ablewhite, J., das Nair, R., Lincoln, N., Kontou, E., Roffe, J., …Drummond, A. (2020). Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke. International Journal of Therapy and Rehabilitation, 27(7),

Background.
There is a paucity of evidence in the UK regarding occupational therapy (OT) cognitive screening, and whether, and how, cognitive impairments are identified and assessed.

Aims
To identify current OT practice for the assessment of c... Read More about Results of a UK-wide vignette study with occupational therapists to explore cognitive screening post-stroke.

The notion of “invisibility” in people’s experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis (2020)
Journal Article
Parker, L. S., Topcu, G., De Boos, D., & das Nair, R. (2021). The notion of “invisibility” in people’s experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis. Disability and Rehabilitation, 43(23), 3276-3290. https://doi.org/10.1080/09638288.2020.1741698

© 2021 Informa UK Limited, trading as Taylor & Francis Group. Purpose: Invisible symptoms have a negative impact on people living with Multiple Sclerosis (MS), related to the very notion that they are “unseen.” It is important to understand the not... Read More about The notion of “invisibility” in people’s experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis.

Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review (2020)
Journal Article
Meek, C., Topcu, G., Moghaddam, N., & das Nair, R. (2021). Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review. Disability and Rehabilitation, 43(22), 3135-3146. https://doi.org/10.1080/09638288.2020.1734105

Purpose: To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS).

Method: We conducted a meta-ethnographic synthesis of qualitative studies on... Read More about Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review.

Self-help Acceptance and Commitment Therapy for Carers of People with Multiple Sclerosis: A Feasibility Randomised Controlled Trial (2020)
Journal Article
Potter, K.-J., Golijana‑Moghaddam, N., Evangelou, N., Mhizha-Murira, J., & Nair, R. (2021). Self-help Acceptance and Commitment Therapy for Carers of People with Multiple Sclerosis: A Feasibility Randomised Controlled Trial. Journal of Clinical Psychology in Medical Settings, 28, 279-294. https://doi.org/10.1007/s10880-020-09711-x

Introduction:

Acceptance and Commitment Therapy (ACT) is an established psychological therapy, but its effectiveness for carers of people with Multiple Sclerosis experiencing carer-related strain has not been established. This study assessed the... Read More about Self-help Acceptance and Commitment Therapy for Carers of People with Multiple Sclerosis: A Feasibility Randomised Controlled Trial.

A lack of association between online pornography exposure, sexual functioning, and mental well-being (2020)
Journal Article
Merdian, H. L., Charig, R., Moghaddam, N. G., Dawson, D. L., & das Nair, R. (2020). A lack of association between online pornography exposure, sexual functioning, and mental well-being. Sexual and Relationship Therapy, 35(2), 258-281. https://doi.org/10.1080/14681994.2020.1727874

© 2020 College of Sexual and Relationship Therapists. To inform debate around potential influences of online pornography, we applied a contemporary media-effects model to examine the relationship between online sexually explicit material (oSEM) expos... Read More about A lack of association between online pornography exposure, sexual functioning, and mental well-being.

Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT (2020)
Journal Article
Lincoln, N. B., Bradshaw, L. E., Constantinescu, C. S., Day, F., Drummond, A. E., Fitzsimmons, D., …CRAMMS Trial Collaborative Group. (2020). Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT. Health Technology Assessment, 24(4), 1-182. https://doi.org/10.3310/hta24040

Abstract
Background
People with multiple sclerosis have problems with memory and attention. The effectiveness of cognitive rehabilitation has not been established.

Objectives
The objectives were to assess the clinical effectiveness and cost-eff... Read More about Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT.

Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review (2019)
Journal Article
Oates, L. L., Moghaddam, N., Evangelou, N., & das Nair, R. (2020). Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review. Clinical Rehabilitation, 34(3), 310-319. https://doi.org/10.1177/0269215519896404

© The Author(s) 2019. Objective: To evaluate the effectiveness of behavioural activation interventions for people with neurological conditions with comorbid depression, and explore content and adaptations. Data sources: PsycINFO, MEDLINE, CINAHL, AME... Read More about Behavioural activation treatment for depression in individuals with neurological conditions: a systematic review.

Cognitive rehabilitation for attention deficits following stroke (2019)
Journal Article
Loetscher, T., Potter, K.-J., Wong, D., & das Nair, R. (2019). Cognitive rehabilitation for attention deficits following stroke. Cochrane Library, https://doi.org/10.1002/14651858.cd002842.pub3

Background
Many survivors of stroke report attentional impairments, such as diminished concentration and distractibility. However, the effectiveness of cognitive rehabilitation for improving these impairments is uncertain.This is an update of the Co... Read More about Cognitive rehabilitation for attention deficits following stroke.

Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT (2019)
Journal Article
Thomas, S. A., Drummond, A. E., Lincoln, N., Palmer, R., das Nair, R., Latimer, N. R., Hackney, G. L., Mandefield, L., Walters, S. J., Hatton, R. D., Cooper, C. L., Chater, T. F., England, T. J., Callaghan, P., Coates, E., Sutherland, K. E., Eshtan, S. J., & Topcu, G. (2019). Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT. Health Technology Assessment, 23(47), https://doi.org/10.3310/hta23470

Beyond current research practice: Methodological considerations in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?) (2019)
Journal Article
das Nair, R., de Groot, V., & Freeman, J. (2019). Beyond current research practice: Methodological considerations in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?). Multiple Sclerosis Journal, 25(10), 1337-1347. https://doi.org/10.1177/1352458519858271

Rehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). MS rehabilitation research has grown considerably, but the volume of robust evidence to guide effective clinical practice in the fo... Read More about Beyond current research practice: Methodological considerations in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?).

A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries (2019)
Journal Article
Kettlewell, J., das Nair, R., & Radford, K. (2019). A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries. Clinical Rehabilitation, 33(11), 1705-1712. https://doi.org/10.1177/0269215519865774

Objective:
This review aimed to determine the effectiveness of personal smart technologies on outcomes in adults with acquired brain injury.

Data sources:
A systematic literature search was conducted on 30 May 2019. Twelve electronic databases,... Read More about A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries.