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All Outputs (58)

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article
Wilkinson-Smith, V., Menys, A., Bradley, C., Corsetti, M., Marciani, L., Atkinson, D., …Hoad, C. (2020). The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge. Neurogastroenterology and Motility, 32(11), Article e13942. https://doi.org/10.1111/nmo.13942

Background

Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy (2020)
Journal Article
Khalaf, A., Hoad, C. L., Blackshaw, E., Alyami, J., Spiller, R. C., Gowland, P. A., …Marciani, L. (2020). Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy. Diagnostics, 10(3), Article 170. https://doi.org/10.3390/diagnostics10030170

Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS sh... Read More about Simultaneous measurement of gastric emptying of a soup test meal using MRI and gamma scintigraphy.

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579. https://doi.org/10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

Enhancing our understanding of small bowel function using modern imaging techniques (2019)
Journal Article
Hoad, C., & Spiller, R. (2020). Enhancing our understanding of small bowel function using modern imaging techniques. Neurogastroenterology and Motility, 32(1), Article e13616. https://doi.org/10.1111/nmo.13616

Small intestinal function is critical to digestive health and patients believe an abnormal reaction to food is responsible for many of their symptoms. Despite this, our ability to assess disturbed function in clinical practice has been limited, parti... Read More about Enhancing our understanding of small bowel function using modern imaging techniques.

Intraluminal impact of food: New insights from MRI (2019)
Journal Article
Marciani, L., & Spiller, R. (2019). Intraluminal impact of food: New insights from MRI. Nutrients, 11(5), Article 1147. https://doi.org/10.3390/nu11051147

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Understanding how the gut responds to food has always been limited by the available investigatory techniques. Previous methods involving intubation and aspiration are largely limited to liquid... Read More about Intraluminal impact of food: New insights from MRI.

Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon (2019)
Journal Article
Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), https://doi.org/10.1111/nmo.13557

Background:
MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal... Read More about Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon.

Spatio-Temporal Motility MRI analysis of the stomach and colon (2019)
Journal Article
Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), Article e13557. https://doi.org/10.1111/nmo.13557

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal m... Read More about Spatio-Temporal Motility MRI analysis of the stomach and colon.

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold (2018)
Journal Article
Hoad, C., Marciani, L., Spiller, R., Gowland, P., & Moran, G. (2019). Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold. Neurogastroenterology and Motility, 31(1), e13466. https://doi.org/10.1111/nmo.13466

Background

The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract in an u... Read More about Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold.

Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging (2018)
Journal Article
Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos-Santiago, A., Kurtz, C. B., Johnston, J., Gowland, P., & Spiller, R. C. (2018). Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility, 30(9), Article e13400. https://doi.org/10.1111/nmo.13400

Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constip... Read More about Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging.

Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon (2018)
Journal Article
Spiller, R. C. (2018). Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon. Cellular and Molecular Gastroenterology and Hepatology, 6(3), 347–348.e1. https://doi.org/10.1016/j.jcmgh.2018.06.005

As we learn more about the importance of our microbiome in inflammatory, metabolic, and functional disorders, we are coming to appreciate the risks of disturbing this with broad-spectrum antibiotics. We have known for many years that as antibiotics h... Read More about Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon.

Post infectious IBS: defining its clinical features and prognosis using an internet-based survey (2018)
Journal Article
Card, T., Enck, P., Barbara, G., Boeckxstaens, G. E., Santos, J., Azpiroz, F., Mearin, F., Aziz, Q., Marshall, J., & Spiller, R. C. (2018). Post infectious IBS: defining its clinical features and prognosis using an internet-based survey. United European Gastroenterology Journal, 6(8), 1245-1253. https://doi.org/10.1177/2050640618779923

Background: Gastrointestinal infection is an important risk factor for developing IBS. Our aim was to characterise postinfectious IBS (PI-IBS) compared to other IBS patients.
Methods: An internet survey of IBS patients using Rome III diagnostic ques... Read More about Post infectious IBS: defining its clinical features and prognosis using an internet-based survey.

Insights into the different effects of food on intestinal secretion using magnetic resonance imaging (2018)
Journal Article
Wilkinson-Smith, V. C., Major, G., Ashleigh, L., Murray, K., Hoad, C. L., Marciani, L., Gowland, P. A., & Spiller, R. C. (2018). Insights into the different effects of food on intestinal secretion using magnetic resonance imaging. Journal of Parenteral and Enteral Nutrition, 42(8), 1342-1348. https://doi.org/10.1002/jpen.1157

Background

Ileostomy output determines need for parenteral fluid support. Plant foods may contain chemicals that stimulate intestinal secretion eg. lactucins in lettuce and rhein in rhubarb. These may account for increases in ileostomy output but... Read More about Insights into the different effects of food on intestinal secretion using magnetic resonance imaging.

Cortical differences in diverticular disease and correlation with symptom reports (2018)
Journal Article
Pitiot, A., Smith, J. K., Garratt, J., Francis, S. T., Gowland, P. A., Spiller, R. C., & Marciani, L. (2018). Cortical differences in diverticular disease and correlation with symptom reports. Neurogastroenterology and Motility, 30(7), Article e13303. https://doi.org/10.1111/nmo.13303

Background

Recent studies have shown that the brain of patients with gastrointestinal disease differ both structurally and functionally from that of controls. Highly somatizing diverticular disease (HSDD) patients were also shown to differ from l... Read More about Cortical differences in diverticular disease and correlation with symptom reports.

Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Alyami, J., Ladd, N., Pritchard, S. E., Hoad, C. L., Abdul Sultan, A., Spiller, R. C., Gowland, P. A., MacDonald, I. A., Aithal, G. P., Marciani, L., & Taylor, M. A. (2017). Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans. Food Research International, https://doi.org/10.1016/j.foodres.2017.11.071

Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.

Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence (2017)
Journal Article
Kruis, W., Kardalinos, V., Eisenbach, T., Lukas, M., Vich, T., Bunganic, I., …Spiller, R. (2017). Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. Alimentary Pharmacology and Therapeutics, 46(3), 282-291. https://doi.org/10.1111/apt.14152

Background

Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in the prevention of recurrent diverticulitis.

Aim

To investigate the efficacy and safety of mesalazine granules in the prevention of recur... Read More about Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence.

Assessment of motion of colonic contents in the human colon using MRI tagging (2017)
Journal Article
Pritchard, S. E., Paul, J., Major, G., Marciani, L., Gowland, P. A., Spiller, R. C., & Hoad, C. (2017). Assessment of motion of colonic contents in the human colon using MRI tagging. Neurogastroenterology and Motility, 29(9), Article e13091. https://doi.org/10.1111/nmo.13091

Background We have previously reported a non-invasive, semi-automated technique to assess motility of the wall of the ascending colon (AC) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged MRI technique to vi... Read More about Assessment of motion of colonic contents in the human colon using MRI tagging.

Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Cox, E., Hoad, C., Pritchard, S. E., Gowland, P. A., & Spiller, R. C. (in press). Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI. American Journal of Gastroenterology, https://doi.org/10.1038/ajg.2016.538

OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.