Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon

Menys, Alex; Hoad, Caroline; Spiller, Robin; Scott, Mark; Atkinson, David; Marciani, Luca; Taylor, Stuart

Abstract

Background:
MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal measurements of contractions, based on changes in bowel lumen diameter.

Methods:
Two heterogeneous cohorts of subjects were selected displaying gastric (n = 15) and colonic motility (n = 20) on which to test the Spatio-Temporal Motility MRI (STMM) technique. STMM involved delineating the bowel lumen along with inner and outer bowel wall along a section of the gastrointestinal tract. A series of diameter measurements were made automatically across the central axis of the lumen. Measurements were automatically propagated through the time series using a previously validated algorithm. Contractions were quantitatively summarised with two methods measuring 1) Normalised Contraction Plot (NCP) and 2) Combined Velocity Distance (CVD) both of which can be visualised as spatiotemporal motility maps. Both metrics were correlated against subjective visual scoring systems.

Key Results:
Good correlation was seen between reader scores and both motility metrics (NCP, R = 0.85, P

Citation

Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI (STMM) analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), https://doi.org/10.1111/nmo.13557

• Journal Article Type: Article
• Acceptance Date: Jan 4, 2019
• Online Publication Date: Feb 28, 2019
• Publication Date: Feb 28, 2019
• Deposit Date: Mar 21, 2019
• Publicly Available Date: Feb 29, 2020
• Journal: Neurogastroenterology and Motility
• Electronic ISSN: 1350-1925
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 5
• DOI: https://doi.org/10.1111/nmo.13557
• Keywords: Gastroenterology; Physiology; Endocrine and Autonomic Systems
• Public URL: https://nottingham-repository.worktribe.com/output/1503993
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13557?af=R
• Additional Information: This is the peer reviewed version of the following article: Menys, A, Hoad, C, Spiller, R, et al. Spatio‐temporal motility MRI analysis of the stomach and colon. Neurogastroenterol Motil. 2019;e13557, which has been published in final form at https://doi.org/10.1111/nmo.13557; . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Mar 21, 2019