All Outputs (3)

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist (2008)
Journal Article
Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., …Stevens, R. C. (2008). The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science, 322(5905), 1211-1217. https://doi.org/10.1126/science.1164772

The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine. We have determined t... Read More about The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors (2008)
Journal Article
Lane, J. R., Powney, B., Wise, A., Rees, S., & Milligan, G. (2008). G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors. Journal of Pharmacology and Experimental Therapeutics, 325(1), 319-330. https://doi.org/10.1124/jpet.107.134296

The human dopamine D2L receptor couples promiscuously to multiple members of the Gαi/o subfamily. Despite the high homology of the D2L and D3 receptors, the G protein coupling specificity of the human D3 receptor is less clearly characterized. The pr... Read More about G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors.

Antibodies that identify only the active conformation of G(i) family G protein alpha subunits (2008)
Journal Article
Lane, J. R., Henderson, D., Powney, B., Wise, A., Rees, S., Daniels, D., …Milligan, G. (2008). Antibodies that identify only the active conformation of G(i) family G protein alpha subunits. FASEB Journal, 22(6), 1924-1932. https://doi.org/10.1096/fj.07-100388

Production of antisera able to recognize individual heterotrimeric G protein alpha subunits resulted in rapid expansion of information on their distribution and function. However, no antibodies that specifically recognize the active state have been a... Read More about Antibodies that identify only the active conformation of G(i) family G protein alpha subunits.