All Outputs (69)

Overcoming multiple drug resistance mechanisms in medulloblastoma (2014)
Journal Article
Othman, R., Coyle, B., Kimishi, I., Bradshaw, T. D., Storer, L., Korshunov, A., Pfister, S., Grundy, R., & Kerr, I. D. (2014). Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta Neuropathologica Communications, 2(1), Article 57. https://doi.org/10.1186/2051-5960-2-57

© 2014 Othman et al.; licensee BioMed Central Ltd. Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We a... Read More about Overcoming multiple drug resistance mechanisms in medulloblastoma.

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells (2014)
Journal Article
Lagah, S., Tan, I.-L., Radhakrishnan, P., Hirst, R. A., Ward, J. H., O'Callaghan, C., Smith, S. J., Stevens, M. F., Grundy, R. G., & Rahman, R. (2014). RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS ONE, 9(1), Article e86187. https://doi.org/10.1371/journal.pone.0086187

Background
Telomeric 3’ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4... Read More about RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors (2013)
Journal Article
Rodriguez Gutierrez, D., Awwad, A., Meijer, L., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. American Journal of Neuroradiology, 35(5), https://doi.org/10.3174/ajnr.A3784

BACKGROUND AND PURPOSE: Qualitative radiologic MR imaging review affords limited differentiation among types of pediatric posterior fossa brain tumors and cannot detect histologic or molecular subtypes, which could help to stratify treatment. This st... Read More about Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.

The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs) (2013)
Journal Article
Rogers, H., Ward, J., Miller, S., Lowe, J., Coyle, B., & Grundy, R. G. (2013). The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs). British Journal of Cancer, 108, https://doi.org/10.1038/bjc.2013.170

Background: Central nervous system primitive neuroectodermal tumours (CNS PNETs) are embryonal tumours occurring predominantly in children. Current lack of knowledge regarding their underlying biology hinders development of more effective treatments... Read More about The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics (2013)
Journal Article
Rodriguez Gutierrez, D., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics. Neuro-Oncology, 15(8), https://doi.org/10.1093/neuonc/not034

Background

Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in a... Read More about Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.

WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma (2012)
Journal Article
Rogers, H., Sousa, S., Salto, C., Arenas, E., Coyle, B., & Grundy, R. G. (2012). WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma. British Journal of Cancer, 107, https://doi.org/10.1038/bjc.2012.377

Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood.... Read More about WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.

Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma (2010)
Journal Article
Rahman, R., Smith, S., Rahman, C., & Grundy, R. (2010). Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. Journal of Oncology, 2010, 1-16. https://doi.org/10.1155/2010/251231

Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis. The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment. Angioge... Read More about Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

Pediatric Ependymoma: Biological Perspectives (2009)
Journal Article
Kilday, J.-P., Rahman, R., Dyer, S., Ridley, L., Lowe, J., Coyle, B., & Grundy, R. (2009). Pediatric Ependymoma: Biological Perspectives. Molecular Cancer Research, 7(6), 765-786. https://doi.org/10.1158/1541-7786.mcr-08-0584

Pediatric ependymomas are enigmatic tumors that continue to present a clinical management challenge despite advances in neurosurgery, neuroimaging techniques, and radiation therapy. Difficulty in predicting tumor behavior from clinical and histologic... Read More about Pediatric Ependymoma: Biological Perspectives.

Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm (2009)
Journal Article
Rahman, R., Heath, R., & Grundy, R. (2009). Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm. BBA - Molecular Basis of Disease, 1792(4), 280-288. https://doi.org/10.1016/j.bbadis.2009.01.011

Brain tumours are a diverse group of neoplasms that continue to present a formidable challenge in our attempt to achieve curable intervention. Our conceptual framework of human brain cancer has been redrawn in the current decade. There is a gathering... Read More about Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.