RUMAN RAHMAN RUMAN.RAHMAN@NOTTINGHAM.AC.UK
Associate Professor
RUMAN RAHMAN RUMAN.RAHMAN@NOTTINGHAM.AC.UK
Associate Professor
STUART SMITH stuart.smith@nottingham.ac.uk
Clinical Associate Professor
Cheryl Rahman
RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology
Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis. The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment. Angiogenesis is a key event in the progression of malignant gliomas, a process involving endothelial cell proliferation, migration, reorganization of extracellular matrix and tube formation. Such processes are regulated by the homeostatic balance between proangiogenic and antiangiogenic factors, most notably vascular endothelial growth factors (VEGFs) produced by glioma cells. Current strategies targeting VEGF-VEGF receptor signal transduction pathways, though effective in normalizing abnormal tumor vasculature, eventually result in tumor resistance whereby a highly infiltrative and invasive phenotype may be adopted. Here we review recent anti-angiogenic therapy for malignant glioma and highlight implantable devices and nano/microparticles as next-generation methods for chemotherapeutic delivery. Intrinsic and adaptive modes of glioma resistance to anti-angiogenic therapy will be discussed with particular focus on the glioma stem cell paradigm.
Rahman, R., Smith, S., Rahman, C., & Grundy, R. (2010). Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. Journal of Oncology, 2010, 1-16. https://doi.org/10.1155/2010/251231
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 2, 2010 |
Publication Date | 2010 |
Deposit Date | Dec 5, 2018 |
Publicly Available Date | Apr 8, 2019 |
Journal | Journal of Oncology |
Print ISSN | 1687-8450 |
Electronic ISSN | 1687-8469 |
Publisher | Hindawi Publishing Corporation |
Peer Reviewed | Peer Reviewed |
Volume | 2010 |
Article Number | 251231 |
Pages | 1-16 |
DOI | https://doi.org/10.1155/2010/251231 |
Public URL | https://nottingham-repository.worktribe.com/output/1370685 |
Publisher URL | https://www.hindawi.com/journals/jo/2010/251231/ |
Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma
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https://creativecommons.org/licenses/by/3.0/
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