All Outputs (4)

Parameter estimation in fluorescence recovery after photobleaching: Quantitative analysis of protein binding reactions and diffusion (2021)
Journal Article

Fluorescence recovery after photobleaching (FRAP) is a common experimental method for investigating rates of molecular redistribution in biological systems. Many mathematical models of FRAP have been developed, the purpose of which is usually the est... Read More about Parameter estimation in fluorescence recovery after photobleaching: Quantitative analysis of protein binding reactions and diffusion.

An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling (2021)
Journal Article

The shuttling of transcription factors and transcriptional regulators into and out of the nucleus is central to the regulation of many biological processes. Here we describe a new method for studying the rates of nuclear entry and exit of transcripti... Read More about An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling.

Reduced biomechanical models for precision-cut lung-slice stretching experiments (2021)
Journal Article

Precision-cut lung-slices (PCLS), in which viable airways embedded within lung parenchyma are stretched or induced to contract, are a widely used ex vivo assay to investigate bronchoconstriction and, more recently, mechanical activation of proremodel... Read More about Reduced biomechanical models for precision-cut lung-slice stretching experiments.

Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation (2021)
Journal Article

Humans and non-human animals show great flexibility in spatial navigation, including the ability to return to specific locations based on as few as one single experience. To study spatial navigation in the laboratory, watermaze tasks, in which rats h... Read More about Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation.