All Outputs (47)

Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis (2005)
Journal Article
Rose, P., Moore, P. K., Ming, S. H., Nam, O. C., Armstrong, J. S., & Whiteman, M. (2005). Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis. World Journal of Gastroenterology, 11(26), 3990-3997. https://doi.org/10.3748/wjg.v11.i26.3990

AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Consi... Read More about Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis.

Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells (2005)
Journal Article
Rose, P., Huang, Q., Ong, C. N., & Whiteman, M. (2005). Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology, 209(2), 105-113. https://doi.org/10.1016/j.taap.2005.04.010

A high dietary intake of cruciferous vegetables has been associated with a reduction in numerous human pathologies particularly cancer. In the current study, we examined the inhibitory effects of broccoli (Brassica oleracea var. italica) and watercre... Read More about Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition (2005)
Journal Article
Whiteman, M., Rose, P., Jia, L. S., Nam, S. C., Gek, S. T., Halliwell, B., & Armstrong, J. S. (2005). Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition. Free Radical Biology and Medicine, 38(12), 1571-1584. https://doi.org/10.1016/j.freeradbiomed.2005.02.030

Liver cirrhosis is often preceded by overt signs of hepatitis, including parenchymal cell inflammation and infiltration of polymorphonuclear (PMN) leukocytes. Activated PMNs release both reactive oxygen species and reactive halogen species, including... Read More about Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition.

β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway (2004)
Journal Article
Rose, P., Armstrong, J. S., Chua, Y. L., Ong, C. N., & Whiteman, M. (2005). β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. International Journal of Biochemistry and Cell Biology, 37(1), 100-119. https://doi.org/10.1016/j.biocel.2004.05.018

The initiating events that lead to the induction of apoptosis mediated by the chemopreventative agent β-phenyethyl isothiocyanate (PEITC) have yet to be elucidated. In the present investigation, we examined the effects of PEITC on mitochondrial funct... Read More about β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant? (2003)
Journal Article
Whiteman, M., Rose, P., & Halliwell, B. (2003). Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?. Biochemical and Biophysical Research Communications, 303(4), 1217-1224. https://doi.org/10.1016/S0006-291X%2803%2900503-5

Acute and chronic inflammation result in increased nitrogen monoxide (̇NO) formation and the accumulation of nitrite (NO2-). Neutrophils stimulated by various inflammatory mediators release myeloperoxidase to produce the cytotoxic agent hypochlorous... Read More about Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?.

Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa (2003)
Journal Article
Rose, P., Widder, S., Looft, J., Pickenhagen, W., Ong, C. N., & Whiteman, M. (2003). Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa. Biochemical and Biophysical Research Communications, 302(2), 397-402. https://doi.org/10.1016/S0006-291X%2803%2900193-1

Peroxynitrite formation in vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products such as thiols as "peroxynitrite scavengers". We therefore investigated the effects of a recen... Read More about Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa.

7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes (2000)
Journal Article
Rose, P., Faulkner, K., Williamson, G., & Mithen, R. (2000). 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis, 21(11), 1983-1988. https://doi.org/10.1093/carcin/21.11.1983

Watercress is an exceptionally rich dietary source of β-phenylethyl isothiocyanate (PEITC). This compound inhibits phase I enzymes, which are responsible for the activation of many carcinogens in animals, and induces phase II enzymes, which are assoc... Read More about 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes.