Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin

Jethwa, Preeti H.; Small, Caroline J.; Smith, Kirsty L.; Seth, Asha; Darch, Sarah J.; Abbott, Caroline R.; Murphy, Kevin G.; Todd, Jeannie F.; Ghatei, Mohammad A.; Bloom, Stephen R.

doi:10.1152/ajpendo.00404.2004

Research Repository

All Outputs (2)

Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release (2005)
Journal Article

Nociceptin or orphanin FQ (N/OFQ) and its receptor NOP1 are expressed in hypothalamic nuclei involved in energy homeostasis. N/OFQ administered by intracerebroventricular or arcuate nucleus (ARC) injection increases food intake in satiated rats. The... Read More about Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release.

Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin (2005)
Journal Article

Intracerebroventricular (ICV) administration of Neuromedin U (NMU), a hypothalamic neuropeptide, or leptin, an adipostat hormone released from adipose tissue, reduces food intake and increases energy expenditure. Leptin stimulates the release of NMU... Read More about Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin.