3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors

Onion, David; Argent, Richard H.; Reece-Smith, Alex M.; Craze, Madeleine L.; Pineda, Robert G.; Clarke, Philip A.; Ratan, Hari L.; Parsons, Simon L.; Lobo, Dileep N.; Duffy, John P.; Atherton, John C.; McKenzie, Andrew J.; Kumari, Rajendra; King, Peter; Hall, Brett M.; Grabowska, Anna M.

doi:10.1158/1535-7163.MCT-15-0598

All Outputs (3)

Individual patient oesophageal cancer 3D models for tailored treatment (2016)
Journal Article

Background: A model to predict chemotherapy response would provide a marked clinical benefit, enabling tailored treatment of oesophageal cancer, where less than half of patients respond to the routinely administered chemotherapy. Methods: Cancer cel... Read More about Individual patient oesophageal cancer 3D models for tailored treatment.

The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment (2016)
Journal Article

In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanote... Read More about The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment.

3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors (2016)
Journal Article

There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug efficacy testing, especially in the era of molecular... Read More about 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors.