Skip to main content

Research Repository

Advanced Search

All Outputs (188)

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims

Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence (2018)
Journal Article
Baker, T. E., Castellanos-Ryan, N., Schumann, G., Cattrell, A., Flor, H., Nees, F., …Conrod, P. J. (2019). Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence. Psychological Medicine, 49(5), 801-810. https://doi.org/10.1017/S0033291718001459

Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both.

Methods: In the present s... Read More about Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.

Risk profiles for heavy drinking in adolescence: differential effects of gender (2018)
Journal Article
Seo, S., Beck, A., Matthis, C., Genauck, A., Banaschewski, T., Bokde, A. L., Bromberg, U., Büchel, C., Quinlan, E. B., Flor, H., Frouin, V., Garavan, H., Gowland, P., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Hohmann, S., …Obermayer, K. (in press). Risk profiles for heavy drinking in adolescence: differential effects of gender. Addiction Biology, https://doi.org/10.1111/adb.12636

Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk pr... Read More about Risk profiles for heavy drinking in adolescence: differential effects of gender.

Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI (2018)
Journal Article
Schwarz, S. T., Mougin, O., Xing, Y., Blazejewska, A., Bajaj, N., Auer, D. P., & Gowland, P. (2018). Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI. NeuroImage: Clinical, 19, 683-689. https://doi.org/10.1016/j.nicl.2018.05.027

Improved markers for the progression of Parkinson's disease (PD) are required. Previous work has proven that iron dependent MRI scans can detect the largest Nigrosome (N1) within the substantia nigra (SN) pars compacta and changes in PD. Histopatholo... Read More about Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI.

Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study (2018)
Journal Article
Palaniyappan, L., Hodgson, O., Balain, V., Iwabuchi, S., Gowland, P., & Liddle, P. (2019). Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study. Psychological Medicine, 49(3), 412-420. https://doi.org/10.1017/S0033291718001010

Background: In patients with schizophrenia, distributed abnormalities are observed in grey matter volume. A recent hypothesis posits that these distributed changes are indicative of a plastic reorganization process occurring in response to a function... Read More about Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study.

Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood (2018)
Journal Article
Albaugh, M., Ivanova, M., Chaarani, B., Orr, C., Allgaier, N., Althoff, R., D'Alberto, N., Hudson, K., Mackey, S., Spechler, P., Banaschewski, T., Bokde, A., Bromberg, U., Cattrell, A., J.Conrod, P., & Gowland, P. (2019). Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. Cerebral Cortex, 29(5), 1866-1874. https://doi.org/10.1093/cercor/bhy066

Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of... Read More about Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood.

Insights into the different effects of food on intestinal secretion using magnetic resonance imaging (2018)
Journal Article
Wilkinson-Smith, V. C., Major, G., Ashleigh, L., Murray, K., Hoad, C. L., Marciani, L., Gowland, P. A., & Spiller, R. C. (2018). Insights into the different effects of food on intestinal secretion using magnetic resonance imaging. Journal of Parenteral and Enteral Nutrition, 42(8), 1342-1348. https://doi.org/10.1002/jpen.1157

Background

Ileostomy output determines need for parenteral fluid support. Plant foods may contain chemicals that stimulate intestinal secretion eg. lactucins in lettuce and rhein in rhubarb. These may account for increases in ileostomy output but... Read More about Insights into the different effects of food on intestinal secretion using magnetic resonance imaging.

Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., …King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), 817-828. https://doi.org/10.1007/s00421-018-3818-y

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More about Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease.

Cortical differences in diverticular disease and correlation with symptom reports (2018)
Journal Article
Pitiot, A., Smith, J. K., Garratt, J., Francis, S. T., Gowland, P. A., Spiller, R. C., & Marciani, L. (2018). Cortical differences in diverticular disease and correlation with symptom reports. Neurogastroenterology and Motility, 30(7), Article e13303. https://doi.org/10.1111/nmo.13303

Background

Recent studies have shown that the brain of patients with gastrointestinal disease differ both structurally and functionally from that of controls. Highly somatizing diverticular disease (HSDD) patients were also shown to differ from l... Read More about Cortical differences in diverticular disease and correlation with symptom reports.

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology (2017)
Journal Article
O'Halloran, L., Cao, Z., Ruddy, K., Jollans, L., Albaugh, M. D., Aleni, A., …Whelan, R. (2018). Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. NeuroImage, 169, https://doi.org/10.1016/j.neuroimage.2017.12.030

Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increa... Read More about Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology.

Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Alyami, J., Ladd, N., Pritchard, S. E., Hoad, C. L., Abdul Sultan, A., Spiller, R. C., Gowland, P. A., MacDonald, I. A., Aithal, G. P., Marciani, L., & Taylor, M. A. (2017). Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans. Food Research International, https://doi.org/10.1016/j.foodres.2017.11.071

Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.

The z-spectrum from human blood at 7T (2017)
Journal Article
Shah, S. M., Mougin, O. E., Carradus, A. J., Geades, N., Dury, R., Morley, W., & Gowland, P. A. (2018). The z-spectrum from human blood at 7T. NeuroImage, 167, https://doi.org/10.1016/j.neuroimage.2017.10.053

Chemical Exchange Saturation Transfer (CEST) has been used to assess healthy and pathological tissue in both animals and humans. However, the CEST signal from blood has not been fully assessed. This paper presents the CEST and nuclear Overhauser enha... Read More about The z-spectrum from human blood at 7T.

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I.-J., Lim, S.-Y., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, https://doi.org/10.1111/jon.12474

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control (2017)
Journal Article
Sadaghiani, S., Ng, B., Altmann, A., Poline, J.-B., Banaschewski, T., Bokde, A. L., …Greicius, M. (2017). Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control. Journal of Neuroscience, 37(40), 9657-9666. https://doi.org/10.1523/JNEUROSCI.0991-17.2017

The nicotinic system plays an important role in cognitive control, and is implicated in several neuropsychiatric conditions. Yet, the contributions of genetic variability in this system to individuals' cognitive control abilities are poorly understoo... Read More about Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control.

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans (2017)
Journal Article
Khalaf, A., Hoad, C., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., …Moran, G. W. (2018). MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology and Motility, 30(1), Article e13182. https://doi.org/10.1111/nmo.13182

Background: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility... Read More about MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.

Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN (2017)
Journal Article
Tan, F. M., Caballero-Gaudes, C., Mullinger, K. J., Cho, S.-Y., Zhang, Y., Dryden, I. L., …Gowland, P. A. (2017). Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN. Human Brain Mapping, 38(11), 5778-5794. https://doi.org/10.1002/hbm.23767

Most functional MRI (fMRI) studies map task-driven brain activity using a block or event-related paradigm. Sparse paradigm free mapping (SPFM) can detect the onset and spatial distribution of BOLD events in the brain without prior timing information,... Read More about Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates: Decoding fMRI Events in SMN.

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article
Murray, K., Hoad, C. L., Mudie, D. M., Wright, J., Heissam, K., Abrehart, N., …Marciani, L. (2017). Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans. Molecular Pharmaceutics, 14(8), 2629-2638. https://doi.org/10.1021/acs.molpharmaceut.7b00095

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More about Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans.

Presence of time-dependent diffusion in the brachial plexus (2017)
Journal Article
Mahbub, Z. B., Peters, A. M., & Gowland, P. A. (2018). Presence of time-dependent diffusion in the brachial plexus. Magnetic Resonance in Medicine, 79(2), 789-795. https://doi.org/10.1002/mrm.26733

© 2017 International Society for Magnetic Resonance in Medicine Purpose: This work describes the development of a method to measure the variation of apparent diffusion coefficient (ADC) with diffusion time (Δ) in the brachial plexus, as a potential m... Read More about Presence of time-dependent diffusion in the brachial plexus.

Psychosocial stress and brain function in adolescent psychopathology (2017)
Journal Article
Quinlan, E. B., Cattrell, A., Jia, T., Artiges, E., Banaschewski, T., Barker, G., …Schumann, G. (2017). Psychosocial stress and brain function in adolescent psychopathology. American Journal of Psychiatry, 174(8), 785-794. https://doi.org/10.1176/appi.ajp.2017.16040464

Objective: To explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships.
Method: Participants w... Read More about Psychosocial stress and brain function in adolescent psychopathology.

Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER (2017)
Journal Article
Chen, C., Sigurdsson, H. P., Pépés, S. E., Auer, D. P., Morris, P. G., Morgan, P. S., …Jackson, S. R. (2017). Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER. NeuroImage, 156, 207-213. https://doi.org/10.1016/j.neuroimage.2017.05.044

Functional magnetic resonance spectroscopy (fMRS) has been used to assess the dynamic metabolic responses of the brain to a physiological stimulus non-invasively. However, only limited information on the dynamic functional response of γ-aminobutyric... Read More about Activation induced changes in GABA: functional MRS at 7 T with MEGA-sLASER.