Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

Albaugh, Matthew; Ivanova, Masha; Chaarani, Bader; Orr, Catherine; Allgaier, Nicholas; Althoff, Robert; D'Alberto, Nicholas; Hudson, Kelse; Mackey, Scott; Spechler, Philip; Banaschewski, Tobias; Bokde, Arun; Bromberg, Uli; Cattrell, Anna; J.Conrod, Patricia; Gowland, Penny

Abstract

Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1,104 participants (M = 14.52 yrs, SD = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -.274, p < .001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

Citation

Albaugh, M., Ivanova, M., Chaarani, B., Orr, C., Allgaier, N., Althoff, R., D'Alberto, N., Hudson, K., Mackey, S., Spechler, P., Banaschewski, T., Bokde, A., Bromberg, U., Cattrell, A., J.Conrod, P., & Gowland, P. (2019). Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. Cerebral Cortex, 29(5), 1866-1874. https://doi.org/10.1093/cercor/bhy066

• Journal Article Type: Article
• Acceptance Date: Feb 26, 2018
• Online Publication Date: Apr 18, 2018
• Publication Date: May 1, 2019
• Deposit Date: Feb 27, 2018
• Publicly Available Date: Apr 19, 2019
• Journal: Cerebral Cortex
• Print ISSN: 1047-3211
• Electronic ISSN: 1460-2199
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 5
• Pages: 1866-1874
• DOI: https://doi.org/10.1093/cercor/bhy066
• Keywords: attention-deficit/hyperactivity disorder, neuroimaging, ventromedial prefrontal cortex
• Public URL: https://nottingham-repository.worktribe.com/output/927012
• Publisher URL: https://academic.oup.com/cercor/article/29/5/1866/4975485
• Additional Information: 37 authors in total.; This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at: https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhy066/4975485
• Contract Date: Feb 27, 2018