All Outputs (5)

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study (2024)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2024). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. NIHR Open Research, 3, Article 65. https://doi.org/10.3310/nihropenres.13510.2

Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung funct... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.

Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review (2024)
Journal Article
Akbar, T., Gershkovich, P., Stamatopoulos, K., Gowland, P. A., Stolnik, S., Butler, J., & Marciani, L. (2024). Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review. Molecular Pharmaceutics, 21(4), 1553-1562. https://doi.org/10.1021/acs.molpharmaceut.3c01123

Oral dosage forms are the most widely and frequently used formulations to deliver active pharmaceutical ingredients (APIs), due to their ease of administration and noninvasiveness. Knowledge of intragastric release rates and gastric mixing is crucial... Read More about Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review.

Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves (2024)
Journal Article
Backhausen, L. L., Fröhner, J. H., Lemaître, H., Artiges, E., Martinot, M. P., Herting, M. M., …Vetter, N. C. (2024). Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves. Human Brain Mapping, 45(3), Article e26574. https://doi.org/10.1002/hbm.26574

Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in st... Read More about Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves.

Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron (2024)
Journal Article
Gunn, D., Yeldho, C., Hoad, C., Menys, A., Gowland, P., Marciani, L., & Spiller, R. (in press). Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14754

Background: Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods: A double-blind, ra... Read More about Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron.

Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization (2024)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., …Marciani, L. (2024). Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization. PLoS ONE, 19(1), Article e0296311. https://doi.org/10.1371/journal.pone.0296311

Recent magnetic resonance imaging (MRI) studies showed that colonic volumes in children are different between health and functional constipation. The length of the colon has however been rarely measured and principally using unphysiological colon pre... Read More about Colon length in pediatric health and constipation measured using magnetic resonance imaging and three dimensional skeletonization.