All Outputs (14)

Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Cox, E., Hoad, C., Pritchard, S. E., Gowland, P. A., & Spiller, R. C. (in press). Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI. American Journal of Gastroenterology, https://doi.org/10.1038/ajg.2016.538

OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.

Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome (2016)
Journal Article
Major, G., Pritchard, S. E., Murray, K., Alappadan, J. P., Hoad, C., Marciani, L., Gowland, P. A., & Spiller, R. C. (2017). Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome. Gastroenterology, 152(1), 124-133.e2. https://doi.org/10.1053/j.gastro.2016.09.062

Background & Aims: Poorly digested, fermentable carbohydrates may induce symptoms of irritable bowel syndrome (IBS), via unclear mechanisms. We performed a randomized trial with magnetic resonance imaging (MRI) analysis to investigate correlations be... Read More about Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome.

Prior consumption of a fat meal in healthy adults modulates the brain’s response to fat (2016)
Journal Article
Eldeghaidy, S., Marciani, L., Hort, J., Hollowood, T. A., Singh, G., Bush, D., Foster, T., Taylor, A. J., Busch, J., Spiller, R. C., Gowland, P. A., & Francis, S. T. (2016). Prior consumption of a fat meal in healthy adults modulates the brain’s response to fat. Journal of Nutrition, 146(11), 2187-2198. https://doi.org/10.3945/jn.116.234104

Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli. Objective: We evaluated how prior consumptio... Read More about Prior consumption of a fat meal in healthy adults modulates the brain’s response to fat.

Comparison of pulsed three-dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state (2016)
Journal Article
Khlebnikov, V., Geades, N., Klomp, D. W., Hoogduin, H., Gowland, P. A., & Mougin, O. (2017). Comparison of pulsed three-dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state. Magnetic Resonance in Medicine, 77(6), 2280-2287. https://doi.org/10.1002/mrm.26323

Purpose: To compare two pulsed, volumetric chemical exchange saturation transfer (CEST) acquisition schemes: steady state (SS) and pseudosteady state (PS) for the same brain coverage, spatial/spectral resolution and scan time. Methods: Both schemes... Read More about Comparison of pulsed three-dimensional CEST acquisition schemes at 7 tesla: steady state versus pseudosteady state.

Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents (2016)
Journal Article
Lancaster, T. M., Linden, D. E., Tansey, K. E., Banaschewski, T., Bokde, A. L., Bromberg, U., …Schumann, G. (in press). Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents. JAMA Psychiatry, 73(8), https://doi.org/10.1001/jamapsychiatry.2016.1135

Importance: Psychotic disorders are characterized by attenuated activity in the brain’s valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging. Objective: To examine... Read More about Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents.

Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents (2016)
Journal Article
Parchetka, C., Strache, N., Raffaelli, B., Gemmeke, I., Weiß, K., Artiges, E., …Gowland, P. A. (in press). Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents. Journal of Public Health, 24, https://doi.org/10.1007/s10389-016-0747-2

Purpose The onset of substance use mostly occurs during adolescence. The aim of the present study is to investigate the relevance of personality on the basis of the NEO-Five-Factor Inventory (NEO-FFI) to future experiences with tobacco, alcohol an... Read More about Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents.

Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD (2016)
Journal Article
Grant, C. J., Harrison, L. E., Hoad, C. L., Marciani, L., Gowland, P. A., & McIntyre, C. W. (2017). Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD. Journal of Gastroenterology and Hepatology, 32(2), 372-377. https://doi.org/10.1111/jgh.13458

Background and Aim: Chronic kidney disease (CKD) affects gastrointestinal (GI) function and results in numerous adaptive and maladaptive responses. Disruption of the colonic microbiome and its attendant consequences—the loss of gut barrier integrity... Read More about Patients with chronic kidney disease have abnormal upper gastro-intestinal tract digestive function: a study of uremic enteropathy: small bowel dysfunction in CKD.

Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity (2016)
Journal Article
Heinrich, A., Müller, K. U., Banaschewski, T., Barker, G. J., Bokde, A. L., Bromberg, U., …Nees, F. (2016). Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity. Biological Psychology, 118, https://doi.org/10.1016/j.biopsycho.2016.05.002

Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during e... Read More about Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity.

Structural brain correlates of adolescent resilience (2016)
Journal Article
Burt, K. B., Whelan, R., Conrod, P. J., Banaschewski, T., Barker, G. J., Bokde, A. L., …Garavan, H. (2016). Structural brain correlates of adolescent resilience. Journal of Child Psychology and Psychiatry, 57(11), 1287-1296. https://doi.org/10.1111/jcpp.12552

Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study... Read More about Structural brain correlates of adolescent resilience.

Ventral striatum connectivity during reward anticipation in adolescent smokers (2016)
Journal Article
Jollans, L., Zhipeng, C., Icke, I., Greene, C., Kelly, C., Banaschewski, T., …Whelan, R. (in press). Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41(1-2), https://doi.org/10.1080/87565641.2016.1164172

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during... Read More about Ventral striatum connectivity during reward anticipation in adolescent smokers.

Mouse and human genetic analyses associate Kalirin with ventral striatal activation during impulsivity and with alcohol misuse (2016)
Journal Article
Peña-Oliver, Y., Carvalho, F. M., Sanchez-Roige, S., Quinlan, E. B., Jia, T., Walker-Tilley, T., …Stephens, D. N. (2016). Mouse and human genetic analyses associate Kalirin with ventral striatal activation during impulsivity and with alcohol misuse. Frontiers in Genetics, 7, Article 52. https://doi.org/10.3389/fgene.2016.00052

Impulsivity is associated with a spectrum of psychiatric disorders including drug addiction. To investigate genetic associations with impulsivity and initiation of drug taking, we took a two-step approach. First, we identified genes whose expression... Read More about Mouse and human genetic analyses associate Kalirin with ventral striatal activation during impulsivity and with alcohol misuse.

Neural basis of reward anticipation and its genetic determinants (2016)
Journal Article
Jia, T., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C., Ji, X., …Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113(14), 3879-3884. https://doi.org/10.1073/pnas.1503252113

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity d... Read More about Neural basis of reward anticipation and its genetic determinants.

Anticipation of thermal pain in diverticular disease (2016)
Journal Article
Smith, J. K., Marciani, L., Humes, D. J., Francis, S. T., Gowland, P. A., & Spiller, R. C. (2016). Anticipation of thermal pain in diverticular disease. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12790

Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.

Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging (2016)
Journal Article
Parker, H. L., Tucker, E., Hoad, C., Pal, A., Costigan, C., Hudders, N., Perkins, A., Blackshaw, E., Gowland, P., Marciani, L., & Fox, M. R. (2016). Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging. Neurogastroenterology and Motility, 28(4), 554-568. https://doi.org/10.1111/nmo.12752

Background: Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Mea... Read More about Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging.