Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans

Murray, Kathryn; Hoad, Caroline L.; Mudie, Deanna M.; Wright, Jeff; Heissam, Khaled; Abrehart, Nichola; Pritchard, Susan E.; Al Atwah, Salem; Gowland, Penny A.; Garnett, Martin C.; Amidon, Greg E.; Spiller, Robin C.; Amidon, Gordon L.; Marciani, Luca

doi:10.1021/acs.molpharmaceut.7b00095

All Outputs (5)

Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review (2024)
Journal Article

Oral dosage forms are the most widely and frequently used formulations to deliver active pharmaceutical ingredients (APIs), due to their ease of administration and noninvasiveness. Knowledge of intragastric release rates and gastric mixing is crucial... Read More about Use of Magnetic Resonance Imaging for Visualization of Oral Dosage Forms in the Human Stomach: A Scoping Review.

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More about Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans.