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All Outputs (16)

Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus (2019)
Journal Article

The gaseous free radical, nitric oxide (NO) acts as a ubiquitous neuromodulator, contributing to synaptic plasticity in a complex way that can involve either long term potentiation or depression. It is produced by neuronal nitric oxide synthase (nNOS... Read More about Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus.

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More about Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.

Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety (2019)
Journal Article

© 2019 American Chemical Society. Amphipathic, nonionic, surfactants are widely used in pharmaceutical, food, and agricultural industry to enhance product features; as pharmaceutical excipients, they are also aimed at increasing cell membrane permeab... Read More about Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety.

Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case (2018)
Journal Article

Aims KATP ion channels play a key role in glucose‐stimulated insulin secretion. However, many drugs block KATP as “off targets” leading to hyperinsulinaemia and hypoglycaemia. As such drugs are often lipophilic, the aim was to examine the relation... Read More about Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case.

Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition (2017)
Journal Article

Diabetes mellitus risk is increased by prolonged usage of antidepressants (ADs). Although various mechanisms are suggested for their diabetogenic potential, whether a direct effect of ADs on pancreatic β-cells is involved is unclear. We examined this... Read More about Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition.

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier (2014)
Journal Article

© 2014 Elsevier B.V. All rights reserved. Although the mechanisms of action of antipsychotics (APs) on neuronal function are well understood, very little is known about their effects on cells of the blood-brain barrier (BBB); one function of which is... Read More about Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.

Hydrogen sulphide mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats (2013)
Journal Article

Background and Purpose Hydrogen sulphide (H2S) is a gas that has recently been shown to have biological activity. In the majority of blood vessels studied so far, H2S has been shown to cause vasorelaxation, although contractile responses have been re... Read More about Hydrogen sulphide mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats.

Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse (2009)
Journal Article

Background: Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal forebrain is the primary regulator of reproductive maturation and function in mammals. Peptidergic signals relating to circadian timing and energy balance... Read More about Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse.