Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification

Brown, Angus M.; Evans, Richard D.; Smith, Paul A.; Rich, Laura R.; Ransom, Bruce R.

doi:10.14814/phy2.14007

All Outputs (4)

Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus (2019)
Journal Article

The gaseous free radical, nitric oxide (NO) acts as a ubiquitous neuromodulator, contributing to synaptic plasticity in a complex way that can involve either long term potentiation or depression. It is produced by neuronal nitric oxide synthase (nNOS... Read More about Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus.

Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function (2019)
Journal Article

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised “off-targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated wit... Read More about Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function.

Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function (2019)
Journal Article

© The Author(s) 2019. Published by Oxford University Press on behalf of the Society of Toxicology. Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognized "off targets" for certain drugs. Simvastatin is one s... Read More about Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function.

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More about Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.