Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake

Constantin-Teodosiu, D.; Cederblad, Gitten; Bergstrom, Mats; Greenhaff, P. L.

doi:10.1016/j.clnu.2018.02.001

All Outputs (4)

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans (2018)
Journal Article

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here,... Read More about Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points (2018)
Journal Article

Loss of muscle mass and insulin sensitivity are common phenotypic traits of immobilisation and increased inflammatory burden. The suppression of muscle protein synthesis is the primary driver of muscle mass loss in human immobilisation, and includes... Read More about The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points.

Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance (2018)
Journal Article

The pattern of metabolic reprogramming in chronic hypoxia shares similarities with that following myocardial infarction or hypertrophy, however the response of the chronically hypoxic heart to subsequent acute injury, and the role of metabolism is no... Read More about Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake (2018)
Journal Article

© 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Exercise activates muscle pyruvate dehydrogenase complex (PDC), but moderate intensity exercise fails to fully activate muscle PDC after high-fat diet [... Read More about Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.