Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

Dom�nguez-Medina, C. Coral; P�rez-Toledo, Marisol; Schager, Anna E.; Marshall, Jennifer L.; Cook, Charlotte N.; Bobat, Saeeda; Hwang, Hyea; Chun, Byeong Jae; Logan, Erin; Bryant, Jack A.; Channell, Will M.; Morris, Faye C.; Jossi, Sian E.; Alshayea, Areej; Rossiter, Amanda E.; Barrow, Paul A.; Horsnell, William G.; MacLennan, Calman A.; Henderson, Ian R.; Lakey, Jeremy H.; Gumbart, James C.; L�pez-Mac�as, Constantino; Bavro, Vassiliy N.; Cunningham, Adam F.

doi:10.1038/s41467-020-14655-9

All Outputs (3)

Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid (2020)
Journal Article
Spankie, T. J., Haywood, A. L., Dottorini, T., Barrow, P. A., & Hirst, J. D. (2020). Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid. Journal of Molecular Graphics and Modelling, 101, Article 107723. https://doi.org/10.1016/j.jmgm.2020.107723

© 2020 Elsevier Inc. One promising strategy to combat antimicrobial resistance is to use bacteriophages that attach to the sex pili produced by transmissible antimicrobial resistance (AMR) plasmids, infect AMR bacteria and select for loss of the AMR... Read More about Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid.

Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage (2020)
Journal Article
Atterbury, R. J., Gigante, A. M., Rubio Lozano, M. D. L. S., Méndez Medina, R. D., Robinson, G., Alloush, H., …Allen, V. M. (2020). Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage. Virology Journal, 17, Article 98. https://doi.org/10.1186/s12985-020-01368-0

Background: Enteric infections caused by Salmonella spp. remain a major public health burden worldwide. Chickens are known to be a major reservoir for this zoonotic pathogen. The presence of Salmonella in poultry farms and abattoirs is associated wit... Read More about Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage.

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface (2020)
Journal Article
Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., …Cunningham, A. F. (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications, 11, Article 851. https://doi.org/10.1038/s41467-020-14655-9

Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric... Read More about Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.