Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells

Sampaziotis, Fotios; de Brito, Miguel Cardoso; Geti, Imbisaat; Bertero, Alessandro; Hannan, Nicholas R.F.; Vallier, Ludovic

doi:10.1038/nprot.2017.011

All Outputs (2)

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency (2018)
Journal Article

© 2018 The Authors Background & Aims: α1-Antitrypsin deficiency (A1ATD) is an autosomal recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant (Gly342Lys) retain polymerised protein in the endoplasmic reticulum (E... Read More about hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells (2017)
Journal Article

The difficulty in isolating and propagating functional primary cholangiocytes is a major limitation in the study of biliary disorders and the testing of novel therapeutic agents. To overcome this problem, we have developed a platform for the differen... Read More about Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.