Structural basis for chain release from the enacyloxin polyketide synthase

Kosol, Simone; Gallo, Angelo; Griffiths, Daniel; Valentic, Timothy R.; Masschelein, Joleen; Jenner, Matthew; de los Santos, Emmanuel L. C.; Manzi, Lucio; Sydor, Paulina K.; Rea, Dean; Zhou, Shanshan; F�l�p, Vilmos; Oldham, Neil J.; Tsai, Shiou-Chuan; Challis, Gregory L.; Lewandowski, J�zef R.

doi:10.1038/s41557-019-0335-5

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Structural basis for chain release from the enacyloxin polyketide synthase (2019)
Journal Article
Kosol, S., Gallo, A., Griffiths, D., Valentic, T. R., Masschelein, J., Jenner, M., …Lewandowski, J. R. (2019). Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11(10), 913-923. https://doi.org/10.1038/s41557-019-0335-5

Modular polyketide synthases and nonribosomal peptide synthetases are molecular assembly lines consisting of several multienzyme subunits that undergo dynamic selfassembly to form a functional mega-complex. N- and C-terminal docking domains are usual... Read More about Structural basis for chain release from the enacyloxin polyketide synthase.