All Outputs (6)

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans (2016)
Journal Article
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., …Atherton, P. J. (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. Journal of Physiology, 594(24), 7399-7417. https://doi.org/10.1113/JP272857

Ageing is associated with impaired hypertrophic responses to resistance exercise training (RET). Here we investigated the aetiology of ‘anabolic resistance’ in older humans. Twenty healthy male individuals, 10 younger (Y; 23 ± 1 years) and 10 older (... Read More about Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C.?elegans muscle. (2016)
Journal Article
Gaffney, C. J., Shephard, F., Chu, J., Baillie, D. L., Rose, A., Constantin‐Teodosiu, T., …Szewczyk, N. (2016). Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle. Journal of Cachexia, Sarcopenia and Muscle, 7(2), 181-192. https://doi.org/10.1002/jcsm.12040

An overview of technical considerations for Western blotting applications to physiological research (2016)
Journal Article
Bass, J. J., Wilkinson, D. J., Rankin, D., Phillips, B. E., Szewczyk, N. J., Smith, K., & Atherton, P. J. (in press). An overview of technical considerations for Western blotting applications to physiological research. Scandinavian Journal of Medicine and Science in Sports, 27(1), https://doi.org/10.1111/sms.12702

The applications of Western/immuno-blotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures in the field of physiology. This is none more so than in relation to skeletal muscle physio... Read More about An overview of technical considerations for Western blotting applications to physiological research.

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development (2016)
Journal Article
Mora-Lorca, J. A., Sáenz-Narciso, B., Gaffney, C. J., Naranjo-Galindo, F. J., Pedrajas, J. R., Guerrero-Gómez, D., …Miranda-Vizuete, A. (in press). Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development. Free Radical Biology and Medicine, 96, https://doi.org/10.1016/j.freeradbiomed.2016.04.017

Glutathione is the most abundant thiol in the vast majority of organisms and is maintained in its reduced form by the flavoenzyme glutathione reductase. In this work, we describe the genetic and functional analysis of the Caenorhabditis elegans gsr-1... Read More about Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.

Fluid dynamics alter Caenorhabditis elegans body length via TGF-?/DBL-1 neuromuscular signaling (2016)
Journal Article
Harada, S., Hashizume, T., Nemoto, K., Shao, Z., Higashitani, N., Etheridge, T., …Higashitani, A. (2016). Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling. npj Microgravity, 2(1), Article 16006. https://doi.org/10.1038/npjmgrav.2016.6

Skeletal muscle wasting is a major obstacle for long-term space exploration. Similar to astronauts, the nematode Caenorhabditis elegans displays negative muscular and physical effects when in microgravity in space. It remains unclear what signaling m... Read More about Fluid dynamics alter Caenorhabditis elegans body length via TGF-?/DBL-1 neuromuscular signaling.

Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans (2016)
Journal Article
Szewczyk, N., Higashibata, A., Hashizume, T., Nemoto, K., Higashitani, N., Etheridge, T., …Higashitani, A. (2016). Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans. npj Microgravity, 2, Article 15022. https://doi.org/10.1038/npjmgrav.2015.22

Although muscle atrophy is a serious problem during spaceflight, little is known about the sequence of molecular events leading to atrophy in response to microgravity. We carried out a spaceflight experiment using Caenorhabditis elegans onboard the J... Read More about Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans.