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What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420) (2020)
Journal Article
French, D. P., Astley, S., Brentnall, A. R., Cuzick, J., Dobrashian, R., Duffy, S. W., …Evans, D. G. (2020). What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420). BMC Cancer, 20, Article 570. https://doi.org/10.1186/s12885-020-07054-2

Background In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more frequent screening and/ or chemo... Read More about What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420).

Improving primary care identification of familial breast cancer risk using proactive invitation and decision support (2020)
Journal Article
Qureshi, N., Dutton, B., Weng, S., Sheehan, C., Chorley, W., Robertson, J. F., …Kai, J. (2021). Improving primary care identification of familial breast cancer risk using proactive invitation and decision support. Familial Cancer, 20(1), 13-21. https://doi.org/10.1007/s10689-020-00188-z

Family history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were recruited from eight English g... Read More about Improving primary care identification of familial breast cancer risk using proactive invitation and decision support.

The introduction of risk stratified screening into the NHS Breast Screening Programme: Views from British-Pakistani women (2020)
Journal Article
Woof, V. G., Ruane, H., French, D. P., Ulph, F., Qureshi, N., Khan, N., …Donnelly, L. S. (2020). The introduction of risk stratified screening into the NHS Breast Screening Programme: Views from British-Pakistani women. BMC Cancer, 20, Article 452. https://doi.org/10.1186/s12885-020-06959-2

Background: UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to identify more high-risk women is... Read More about The introduction of risk stratified screening into the NHS Breast Screening Programme: Views from British-Pakistani women.

Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study (2020)
Journal Article
Zghebi, S. S., Mamas, M. A., Ashcroft, D. M., Salisbury, C., Mallen, C. D., Chew-Graham, C. A., …Kontopantelis, E. (2020). Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Research and Care, 8(1), Article e000962. https://doi.org/10.1136/bmjdrc-2019-000962

Objective: Clinically-applicable diabetes severity measures are lacking, with no previous studies compared their predictive value to HbA1c. We developed and validated a type 2 diabetes severity score (DISSCO) and evaluated its association with risks... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study.

Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care (2020)
Journal Article
Lee, S. I., Kai, J., Qureshi, N., Dutton, B., & Weng, S. (2020). Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care. Journal of Community Genetics, 11, 331–338. https://doi.org/10.1007/s12687-020-00452-w

© 2020, The Author(s). Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characte... Read More about Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.

Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women (2019)
Journal Article
Woof, V. G., Ruane, H., Ulph, F., French, D. P., Qureshi, N., Khan, N., …Donnelly, L. S. (2020). Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women. Journal of Medical Screening, 27(3), 130-137. https://doi.org/10.1177/0969141319887405

Objectives: Previous research has largely attempted to explore breast screening experiences of South Asian women by combining opinions from Pakistani, Bangladeshi and Indian women. This research often fails to reach the most underserved sub-groups of... Read More about Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women.

HEART UK consensus statement on Lipoprotein(a): A call to action (2019)
Journal Article
Cegla, J., Neely, R. D. G., France, M., Ferns, G., Byrne, C. D., Halcox, J., …for the HEART UK Medical, Scientific and Research Committee. (2019). HEART UK consensus statement on Lipoprotein(a): A call to action. Atherosclerosis, 291, 62-70. https://doi.org/10.1016/j.atherosclerosis.2019.10.011

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a... Read More about HEART UK consensus statement on Lipoprotein(a): A call to action.

How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise (2019)
Journal Article
Salway, S., Yazici, E., Khan, N., Ali, P., Elmslie, F., Thompson, J., & Qureshi, N. (2019). How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise. BMJ Open, 9(7), Article e028928. https://doi.org/10.1136/bmjopen-2019-028928

Objectives: (1) To explore professional and lay stakeholder views on the design and delivery of services in the area of consanguinity and genetic risk. (2) To identify principles on which there is sufficient consensus to warrant inclusion in a nation... Read More about How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise.

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Iyen, B., Qureshi, N., Leonardi-Bee, J., Kai, J., Akyea, R. K., Roderick, P., …Weng, S. (2019). Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study. Atherosclerosis, 287, 8-15. https://doi.org/10.1016/j.atherosclerosis.2019.05.017

Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More about Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, 105(13), 975-981. https://doi.org/10.1136/heartjnl-2018-314253

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More about Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review (2019)
Journal Article
Zghebi, S. S., Panagioti, M., Rutter, M. K., Ashcroft, D. M., van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2019). Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review. Diabetic Medicine, 36(6), 688-701. https://doi.org/10.1111/dme.13905

Aims: To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods: We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data‐based diabetes‐sp... Read More about Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review.

Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice (2018)
Journal Article
Holt, T. A., Dalton, A. R., Kirkpatrick, S., Hislop, J., Marshall, T., Fay, M., …Hobbs, F. R. (2018). Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice. British Journal of General Practice, 68(677), e844-e851. https://doi.org/10.3399/bjgp18x699809

Background: Oral anticoagulants reduce the risk of stroke in patients with atrial fibrillation (AF), but are underused. AURAS-AF (AUtomated Risk Assessment for Stroke in AF) is a software tool designed to identify eligible patients and promote discus... Read More about Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice.

Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part (2018)
Journal Article
Brett, T., Qureshi, N., Gidding, S., & Watts, G. F. (2018). Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part. Atherosclerosis, 277, 399-406. https://doi.org/10.1016/j.atherosclerosis.2018.08.019

Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are c... Read More about Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Zghebi, S. S., Rutter, M. K., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C. A., …Planner, C. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, 8(6), Article e020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales (2018)
Journal Article
Crosland, P., Maconachie, R., Buckner, S., McGuire, H., Humphries, S. E., & Qureshi, N. (2018). Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales. Atherosclerosis, 275, https://doi.org/10.1016/j.atherosclerosis.2018.05.021

Background and aims: The cost effectiveness of cascade testing for familial hypercholesterolaemia (FH) is well recognised. Less clear is the cost effectiveness of FH screening when it includes case identification strategies that incorporate routinely... Read More about Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales.

Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings (2018)
Journal Article
Qureshi, N., Weng, S. F., Tranter, J. A., Da Silva, M. L., Kai, J., & Leonardi-Bee, J. (2018). Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings. Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012985

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The purpose of this review is to assess the effectiveness of interventions to systematically improve identification of FH in non-specialist settings compared t... Read More about Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings.