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Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development (2020)
Journal Article
Carabelli, A. M., Isgró, M., Sanni, O., Figueredo, G. P., Winkler, D. A., Burroughs, L., …Alexander, M. R. (2020). Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development. ACS Applied Bio Materials, 3(12), 8471–8480. https://doi.org/10.1021/acsabm.0c00849

© 2020 American Chemical Society. Bacterial biofilms exhibit up to 1000 times greater resistance to antibiotic or host immune clearance than planktonic cells. Pseudomonas aeruginosa produces retractable type IV pili (T4P) that facilitate twitching mo... Read More about Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development.

Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines (2020)
Journal Article
Edney, M. K., Lamb, J. S., Spanu, M., Smith, E. F., Steer, E., Wilmot, E., …Scurr, D. J. (2020). Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines. ACS Applied Materials and Interfaces, 12(45), 51026-51035. https://doi.org/10.1021/acsami.0c14532

Internal combustion engines are used heavily in diverse applications worldwide. Achieving the most efficient operation is key to improving air quality as society moves to a decarbonized energy system. Insoluble deposits that form within internal comb... Read More about Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines.

Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering (2020)
Journal Article
Amer, M. H., Alvarez-Paino, M., McLaren, J., Pappalardo, F., Trujillo, S., Wong, J. Q., …Rose, F. R. (2021). Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. Biomaterials, 266, Article 120450. https://doi.org/10.1016/j.biomaterials.2020.120450

© 2020 The Authors Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential of microparticles as modulating moieties of osteogenic response by utilizing their architectural features is demonstrated... Read More about Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering.

All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2 (2020)
Journal Article
Xue, X., Ball, J. K., Alexander, C., & Alexander, M. R. (2020). All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2. Matter, 3(5), 1433-1441. https://doi.org/10.1016/j.matt.2020.10.006

© 2020 Elsevier Inc. The world faces a severe and acute public health emergency due to the ongoing coronavirus disease 2019 (COVID-19) global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Healthcare workers are... Read More about All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2.

Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties (2020)
Journal Article
Alobaid, M. A., Richards, S., Alexander, M. R., Gibson, M. I., & Ghaemmaghami, A. M. (2020). Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. Materials Today Bio, 8, https://doi.org/10.1016/j.mtbio.2020.100080

© 2020 The Authors New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their abi... Read More about Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

Discovery of hemocompatible bacterial biofilm-resistant copolymers (2020)
Journal Article
Singh, T., Hook, A. L., Luckett, J., Maitz, M. F., Sperling, C., Werner, C., …Alexander, M. R. (2020). Discovery of hemocompatible bacterial biofilm-resistant copolymers. Biomaterials, 260, Article 120312. https://doi.org/10.1016/j.biomaterials.2020.120312

© 2020 The Authors Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with t... Read More about Discovery of hemocompatible bacterial biofilm-resistant copolymers.

Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants (2020)
Journal Article
Dundas, A. A., Cuzzucoli Crucitti, V., Haas, S., Dubern, J., Latif, A., Romero, M., …Irvine, D. J. (2020). Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants. Advanced Functional Materials, 30(36), https://doi.org/10.1002/adfm.202001821

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A flow-focusing microfluidic device is used to produce functionalized monodisperse polymer particles with surface chemistries designed to control bacterial biofilm formatio... Read More about Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants.

Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration (2020)
Journal Article
Vallieres, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G., Davies, C. R., …Avery, S. V. (2020). Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances, 6(23), Article eaba6574. https://doi.org/10.1126/sciadv.aba6574

© 2020 The Authors. Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passivel... Read More about Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
Journal Article
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., …Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article
Vassey, M. J., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., …Alexander, M. R. (2020). Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation. Advanced Science, 7(11), https://doi.org/10.1002/advs.201903392

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.

ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray (2020)
Journal Article
Gardner, W., Hook, A. L., Alexander, M. R., Ballabio, D., Cutts, S. M., Muir, B. W., & Pigram, P. J. (2020). ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray. Analytical Chemistry, 92(9), 6587-6597. https://doi.org/10.1021/acs.analchem.0c00349

© 2020 American Chemical Society. Combinatorial approaches to materials discovery offer promising potential for the rapid development of novel polymer systems. Polymer microarrays enable the high-throughput comparison of material physical and chemica... Read More about ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray.

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections (2020)
Journal Article
Kurmoo, Y., Hook, A. L., Harvey, D., Dubern, J., Williams, P., Morgan, S. P., …Alexander, M. R. (2020). Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomaterials Science, 8(5), 1464-1477. https://doi.org/10.1039/c9bm00875f

Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre se... Read More about Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections.

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article
Yoo, J., Clark, E. A., Wallace, M. J., Irvine, D. J., Alexander, M. R., Roberts, C. J., & Wildman, R. D. (2020). Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing. International Journal of Pharmaceutics, 578, https://doi.org/10.1016/j.ijpharm.2019.118805

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation (2019)
Journal Article
Dundas, A. A., Sanni, O., Dubern, J., Dimitrakis, G., Hook, A. L., Irvine, D. J., …Alexander, M. R. (2019). Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation. Advanced Materials, 31(49), Article 1903513. https://doi.org/10.1002/adma.201903513

ynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day o... Read More about Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation.

Toward Interpretable Machine Learning Models for Materials Discovery (2019)
Journal Article
Mikulskis, P., Alexander, M. R., & Winkler, D. A. (2019). Toward Interpretable Machine Learning Models for Materials Discovery. Advanced Intelligent Systems, 1(8), Article 1900045. https://doi.org/10.1002/aisy.201900045

Machine learning (ML) and artificial intelligence (AI) methods for modeling useful materials properties are now important technologies for rational design and optimization of bespoke functional materials. Although these methods make good predictions... Read More about Toward Interpretable Machine Learning Models for Materials Discovery.

Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators (2019)
Journal Article
Hook, A. L., Flewellen, J. L., Dubern, J., Carabelli, A., Zald, I. M., Berry, R. M., …Alexander, M. R. (2019). Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators. mSystems, 4(5), Article e00390-19. https://doi.org/10.1128/mSystems.00390-19

Bacteria sense chemicals, surfaces, and other cells and move toward some and away from others. Studying how single bacterial cells in a population move requires sophisticated tracking and imaging techniques. We have established quantitative methodolo... Read More about Simultaneous Tracking of Pseudomonas aeruginosa motility in liquid and at the Solid-Liquid Interface Reveals Differential Roles for the Flagellar Stators.

Wireless Nanobioelectronics for Electrical Intracellular Sensing (2019)
Journal Article
Sanjuan-Alberte, P., Jain, A., Shaw, A. J., Abayzeed, S. A., Domínguez, R. F., Alea-Reyes, M. E., …Rawson, F. J. (2019). Wireless Nanobioelectronics for Electrical Intracellular Sensing. ACS Applied Nano Materials, 2(10), 6397-6408. https://doi.org/10.1021/acsanm.9b01374

For the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of “wireless” electronic systems to enable modulation of chemistry inside of cells. Herein we report on an intracellular wireless elec... Read More about Wireless Nanobioelectronics for Electrical Intracellular Sensing.

Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo (2019)
Journal Article
Singh, N., Romero, M., Travanut, A., Monteiro, P., Jordana-Lluch, E., Hardie, K. R., …Alexander, C. (2019). Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo. Biomaterials Science, 10(7), 4099-4111. https://doi.org/10.1039/C9BM00773C

Many debilitating infections result from persistent microbial biofilms that do not respond to conventional antibiotic regimens. A potential method to treat such chronic infections is to combine agents which interfere with bacterial biofilm developmen... Read More about Dual Bioresponsive Antibiotic and Quorum Sensing Inhibitor Combination Nanoparticles for Treatment of Pseudomonas aeruginosa Biofilms In Vitro and Ex Vivo.

Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior (2019)
Journal Article
Vaithilingam, J., Sanjuan‐Alberte, P., Campora, S., Rance, G. A., Jiang, L., Thorpe, J., …Rawson, F. J. (2019). Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior. Advanced Functional Materials, 29(38), Article 1902016. https://doi.org/10.1002/adfm.201902016

Biological structures control cell behavior via physical, chemical, electrical, and mechanical cues. Approaches that allow us to build devices that mimic these cues in a combinatorial way are lacking due to there being no suitable instructive materia... Read More about Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior.

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations (2019)
Journal Article
Zhou, Z., Ruiz Cantu, L., Chen, X., Alexander, M. R., Roberts, C. J., Hague, R., …Wildman, R. (2019). High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations. Additive Manufacturing, 29, Article 100792. https://doi.org/10.1016/j.addma.2019.100792

Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting... Read More about High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations.