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Water contact angle is not a good predictor of biological responses to materials

Alexander, Morgan R.; Williams, Paul

Authors

Morgan R. Alexander

Paul Williams



Abstract

Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions.

Journal Article Type Article
Journal Biointerphases
Print ISSN 1934-8630
Electronic ISSN 1934-8630
Publisher AIP Publishing
Peer Reviewed Peer Reviewed
Volume 12
Issue 2
Article Number 02C201
APA6 Citation Alexander, M. R., & Williams, P. (in press). Water contact angle is not a good predictor of biological responses to materials. Biointerphases, 12(2), doi:10.1116/1.4989843
DOI https://doi.org/10.1116/1.4989843
Publisher URL http://avs.scitation.org/doi/abs/10.1116/1.4989843
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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