Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

Portelli, Michael A.; Dijk, F. Nicole; Ketelaar, Maria E.; Shrine, Nick; Hankinson, Jenny; Bhaker, Sangita; Grotenboer, N�omi S.; Obeidat, Ma�en; Henry, Amanda P.; Billington, Charlotte K.; Shaw, Dominick; Johnson, Simon R.; Pogson, Zara E.K.; Fogarty, Andrew; McKeever, Tricia M.; Nickle, David C.; Boss�, Yohan; van den Berge, Maarten; Faiz, Alen; Brouwer, Sharon; Vonk, Judith M.; de Vos, Paul; Brandsma, Corry Anke; Vermeulen, Corneel; Singapuri, Amisha; Heaney, Liam G.; Mansur, Adel H.; Chaudhuri, Rekha; Thomson, Neil C.; Holloway, John W.; Lockett, Gabrielle A.; Howarth, Peter H.; Niven, Robert; Simpson, Angela; Blakey, John D.; Tobin, Martin D.; Postma, Dirkje S.; Hall, Ian P.; Wain, Louise V.; Nawijn, Martijn C.; Brightling, Christopher E.; Koppelman, Gerard H.; Sayers, Ian

doi:10.1172/jci.insight.132446

All Outputs (1)

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.