All Outputs (25)

A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance (2023)
Journal Article
Pitsili, E., Rodriguez‐Trevino, R., Ruiz‐Solani, N., Demir, F., Kastanaki, E., Dambire, C., …Coll, N. S. (2023). A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance. New Phytologist, https://doi.org/10.1111/nph.19022

Increasing drought phenomena pose a serious threat to agricultural productivity. Although plants have multiple ways to respond to the complexity of drought stress, the underlying mechanisms of stress sensing and signaling remain unclear. The role of... Read More about A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance.

Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana (2022)
Journal Article
Lou, S., Guo, X., Liu, L., Song, Y., Zhang, L., Jiang, Y., …Liu, J. (2022). Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana. Science Advances, 8(18), Article eabn8281. https://doi.org/10.1126/sciadv.abn8281

Populations of widespread species are usually geographically distributed through contrasting stresses, but underlying genetic mechanisms controlling this adaptation remain largely unknown. Here, we show that in Arabidopsis thaliana, allelic changes i... Read More about Allelic shift in cis-elements of the transcription factor RAP2.12 underlies adaptation associated with humidity in Arabidopsis thaliana.

Comparative Biology of Oxygen Sensing in Plants and Animals (2020)
Journal Article
Gibbs, D. J., & Holdsworth, M. J. (2020). Comparative Biology of Oxygen Sensing in Plants and Animals. Current Biology, 30(8), R362-R369. https://doi.org/10.1016/j.cub.2020.03.021

© 2020 Elsevier Inc. Aerobic respiration is essential to almost all eukaryotes and sensing oxygen is a key determinant of survival. Analogous but mechanistically different oxygen-sensing pathways were adopted in plants and metazoan animals, and inclu... Read More about Comparative Biology of Oxygen Sensing in Plants and Animals.

The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development (2020)
Journal Article
Labandera, A., Tedds, H. M., Bailey, M., Sprigg, C., Etherington, R. D., Akintewe, O., …Gibbs, D. J. (2021). The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development. New Phytologist, 229(1), 126-139. https://doi.org/10.1111/nph.16477

© 2020 The Authors. New Phytologist © 2020 New Phytologist Trust VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2)-regulated target of the PCO branch of the PRT6 N-degron pathway of u... Read More about The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.

The plant N‐degron pathways of ubiquitin‐mediated proteolysis (2019)
Journal Article
Holdsworth, M. J., Vicente, J., Sharma, G., Abbas, M., & Zubrycka, A. (2020). The plant N‐degron pathways of ubiquitin‐mediated proteolysis. Journal of Integrative Plant Biology, 62(1), 70-89. https://doi.org/10.1111/jipb.12882

The amino‐terminal residue of a protein (or amino‐terminus of a peptide following protease cleavage) can be an important determinant of its stability, through the Ubiquitin‐Proteasome‐System associated N‐degron pathways. Plants contain a unique combi... Read More about The plant N‐degron pathways of ubiquitin‐mediated proteolysis.

Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress (2019)
Journal Article
Hartman, S., Liu, Z., Van Veen, H., Vicente, J., Reinen, E., Martopawiro, S., …Voesenek, L. A. (2019). Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress. Nature Communications, 10, Article 4020. https://doi.org/10.1038/s41467-019-12045-4

Timely perception of adverse environmental changes is critical for survival. Dynamic changes in gases are important cues for plants to sense environmental perturbations, such as submergence. In Arabidopsis thaliana, changes in oxygen and nitric oxide... Read More about Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress.

The Scope, Functions, and Dynamics of Posttranslational Protein Modifications (2019)
Journal Article
Millar, A. H., Heazlewood, J. L., Giglione, C., Holdsworth, M. J., Bachmair, A., & Schulze, W. X. (2019). The Scope, Functions, and Dynamics of Posttranslational Protein Modifications. Annual Review of Plant Biology, 70, 119-151. https://doi.org/10.1146/annurev-arplant-050718-100211

© 2019 by Annual Reviews. All rights reserved. Assessing posttranslational modification (PTM) patterns within protein molecules and reading their functional implications present grand challenges for plant biology. We combine four perspectives on PTMs... Read More about The Scope, Functions, and Dynamics of Posttranslational Protein Modifications.

A regulatory module controlling GA-mediated endosperm cell expansion is critical for seed germination in Arabidopsis (2018)
Journal Article
Sánchez-Montesino, R., Bouza-Morcillo, L., Marquez, J., Ghita, M., Duran-Nebreda, S., Gómez, L., …Oñate-Sánchez, L. (2019). A regulatory module controlling GA-mediated endosperm cell expansion is critical for seed germination in Arabidopsis. Molecular Plant, 12(1), 71-85. https://doi.org/10.1016/j.molp.2018.10.009

A key component of seed germination is the interplay of mechanical forces governing embryo growth and the surrounding restraining endosperm tissue. Endosperm cell separation is therefore thought to play a critical role in the control of this developm... Read More about A regulatory module controlling GA-mediated endosperm cell expansion is critical for seed germination in Arabidopsis.

Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment (2018)
Journal Article
Zhang, H., Gannon, L., Jones, P. D., Rundle, C. A., Hassall, K. L., Gibbs, D. J., …Theodoulou, F. L. (2018). Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment. Scientific Reports, 8(1), Article 15192. https://doi.org/10.1038/s41598-018-33630-5

The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant development, notably in the transition from dormant seed to photoautotrophic seedling. PROTEOLYSIS6 (PRT6), an N-recognin E3 ligase of the Arg/N-end... Read More about Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment.

N-term 2017: Proteostasis via the N-terminus (2017)
Journal Article
Dissmeyer, N., Graciet, E., Holdsworth, M. J., & Gibbs, D. J. (in press). N-term 2017: Proteostasis via the N-terminus. Trends in Biochemical Sciences, https://doi.org/10.1016/j.tibs.2017.11.006

N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for i... Read More about N-term 2017: Proteostasis via the N-terminus.

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway (2017)
Journal Article
Zhang, H., Gannon, L., Hassall, K. L., Deery, M. J., Gibbs, D. J., Holdsworth, M. J., …Theodoulou, F. L. (in press). N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway. New Phytologist, https://doi.org/10.1111/nph.14909

The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the... Read More about N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.

First hints of new sensors (2017)
Journal Article
Holdsworth, M. J. (in press). First hints of new sensors. Nature Plants, 3, https://doi.org/10.1038/s41477-017-0031-7

A mechanism by which plants detect and respond to oxygen starvation has been known for some years. Three recent papers suggest that we haven’t been seeing the full picture.

Community recommendations on terminology and procedures used in flooding and low oxygen stress research (2017)
Journal Article
Sasidharan, R., Bailey-Serres, J., Ashikari, M., Atwell, B. J., Colmer, T. D., Fagerstedt, K., …Voesenek, L. A. C. J. (2017). Community recommendations on terminology and procedures used in flooding and low oxygen stress research. New Phytologist, 214(4), 1403-1407. https://doi.org/10.1111/nph.14519

Apart from playing a key role in important biochemical reactions, molecular oxygen (O2) and its by-products also have crucial signaling roles in shaping plant developmental programs and environmental responses. Even under normal conditions, sharp O2... Read More about Community recommendations on terminology and procedures used in flooding and low oxygen stress research.

Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot (2016)
Journal Article
Gravot, A., Richard, G., Lime, T., Lemarié, S., Jubault, M., Lariagon, C., …Manzanares-Dauleux, M. J. (2016). Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot. BMC Plant Biology, 16, Article 251. https://doi.org/10.1186/s12870-016-0941-y

Background The induction of alcohol fermentation in roots is a plant adaptive response to flooding stress and oxygen deprivation. Available transcriptomic data suggest that fermentation-related genes are also frequently induced in roots infected w... Read More about Hypoxia response in Arabidopsis roots infected by Plasmodiophora brassicae supports the development of clubroot.

Dormant and after-ripened Arabidopsis thaliana seeds are distinguished by early transcriptional differences in the imbibed state (2016)
Journal Article
Dekkers, B. J., Pearce, S. P., van Bolderen-Veldkamp, R., Holdsworth, M. J., & Bentsink, L. (2016). Dormant and after-ripened Arabidopsis thaliana seeds are distinguished by early transcriptional differences in the imbibed state. Frontiers in Plant Science, 7(AUG2016), Article 1323. https://doi.org/10.3389/fpls.2016.01323

Seed dormancy is a genetically controlled block preventing the germination of imbibed seeds in favorable conditions. It requires a period of dry storage (after-ripening) or certain environmental conditions to be overcome. Dormancy is an important see... Read More about Dormant and after-ripened Arabidopsis thaliana seeds are distinguished by early transcriptional differences in the imbibed state.

From start to finish: amino-terminal protein modifications as degradation signals in plants (2016)
Journal Article
Gibbs, D. J., Bailey, M., Tedds, H. M., & Holdsworth, M. J. (2016). From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211(4), 1188-1194. https://doi.org/10.1111/nph.14105

The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated... Read More about From start to finish: amino-terminal protein modifications as degradation signals in plants.

The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm (2016)
Journal Article
Shorinola, O., Bird, N., Simmonds, J., Berry, S., Henriksson, T., Jack, P., …Uauy, C. (2016). The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm. Journal of Experimental Botany, 67(14), 4169-4178. https://doi.org/10.1093/jxb/erw194

The precocious germination of cereal grains before harvest, also known as pre-harvest sprouting, is an important source of yield and quality loss in cereal production. Pre-harvest sprouting is a complex grain defect and is becoming an increasing chal... Read More about The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm.

Group VII ethylene response factors coordinate oxygen and nitric oxide signal transduction and stress responses in plants (2015)
Journal Article
Gibbs, D. J., Vincente Conde, J., Berckhan, S., Prasad, G., Mendiondo, G. M., & Holdsworth, M. J. (2015). Group VII ethylene response factors coordinate oxygen and nitric oxide signal transduction and stress responses in plants. Plant Physiology, 169(1), https://doi.org/10.1104/pp.15.00338

The group VII ethylene response factors (ERFVIIs) are plant-specific transcription factors that have emerged as important regulators of abiotic and biotic stress responses, in particular, low-oxygen stress. A defining feature of ERFVIIs is their cons... Read More about Group VII ethylene response factors coordinate oxygen and nitric oxide signal transduction and stress responses in plants.

Multi-omics analysis identifies genes mediating the extension of cell walls in the Arabidopsis thaliana root elongation zone (2015)
Journal Article
Wilson, M. H., Holman, T. J., Sørensen, I., Cancho-Sanchez, E., Wells, D. M., Swarup, R., …Hodgman, T. C. (2015). Multi-omics analysis identifies genes mediating the extension of cell walls in the Arabidopsis thaliana root elongation zone. Frontiers in Cell and Developmental Biology, 3(FEB), Article 10. https://doi.org/10.3389/fcell.2015.00010

Plant cell wall composition is important for regulating growth rates, especially in roots. However, neither analyses of cell wall composition nor transcriptomes on their own can comprehensively reveal which genes and processes are mediating growth an... Read More about Multi-omics analysis identifies genes mediating the extension of cell walls in the Arabidopsis thaliana root elongation zone.

Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6 (2015)
Journal Article
Mendiondo, G. M., Gibbs, D. J., Szurman-Zubrzycka, M., Korn, A., Marquez, J., Szarejko, I., …Holdsworth, M. J. (2016). Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6. Plant Biotechnology Journal, 14(1), 40-50. https://doi.org/10.1111/pbi.12334

© 2016 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd. Increased tolerance of crops to low oxygen (hypoxia) during flooding is a key target for food security. In Arabidopsis thaliana (L.) Heynh., the N... Read More about Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.