All Outputs (10)

High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications.

High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation (2020)
Journal Article
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., …Corsetti, M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Neurogastroenterology and Motility, 33(6), 1-21. https://doi.org/10.1111/nmo.14050

Chronic constipation is a prevalent disorder that affects patients’ quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treat... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation.

In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal (2020)
Journal Article
Maruca, A., Lupia, A., Rocca, R., Keszthelyi, D., Corsetti, M., & Alcaro, S. (2020). In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal. International Journal of Molecular Sciences, 21(23), Article 9127. https://doi.org/10.3390/ijms21239127

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In... Read More about In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal.

Irritable Bowel Syndrome (2020)
Journal Article
Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020). Irritable Bowel Syndrome. Lancet, 396(10263), 1675-1688. https://doi.org/10.1016/S0140-6736%2820%2931548-8

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose symptoms include abdominal pain associated with a change in stool form or frequency. The condition affects between 5% and 10% of otherwise healthy individuals in the commu... Read More about Irritable Bowel Syndrome.

Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test? (2020)
Journal Article
Basilisco, B., & Corsetti, M. (2020). Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?. Neurogastroenterology and Motility, 32(10), Article e14001. https://doi.org/10.1111/nmo.14001

Symptoms such as a feeling of incomplete evacuation, straining, absence of the call to stool, anal blockage or digitation suggest the presence a functional defecation disorder. As symptoms do not distinguish between patients with and without function... Read More about Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?.

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications (2020)
Journal Article
Augustijns, P., Vertzoni, M., Reppas, C., Langguth, P., Lennernäs, H., Abrahamsson, B., …Hens, B. (2020). Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications. European Journal of Pharmaceutical Sciences, 155, Article 105517. https://doi.org/10.1016/j.ejps.2020.105517

Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption... Read More about Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications.

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article
Wilkinson-Smith, V., Menys, A., Bradley, C., Corsetti, M., Marciani, L., Atkinson, D., …Hoad, C. (2020). The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge. Neurogastroenterology and Motility, 32(11), Article e13942. https://doi.org/10.1111/nmo.13942

Background

Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study (2020)
Journal Article
Vork, L., Keszthelyi, D., van Kuijk, S. M., Quetglas, E. G., Törnblom, H., Simrén, M., …Masclee, A. A. (2020). Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study. Clinical and Translational Gastroenterology, 11(7), Article e00209. https://doi.org/10.14309/ctg.0000000000000209

INTRODUCTION:

Gastrointestinal symptoms in irritable bowel syndrome (IBS) have been correlated with psychological factors using retrospective symptom assessment. However, real-time symptom assessment might reveal the interplay between abdominal a... Read More about Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study.

Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism (2020)
Journal Article
Dent, J., Dinning, P., Corsetti, M., Rommel, N., Tack, J., Wiklendt, L., …Deloose, E. (2020). Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism. Neurogastroenterology and Motility, 32(10), Article e13835. https://doi.org/10.1111/nmo.13835

© 2020 John Wiley & Sons Ltd Background: High-resolution manometric studies below the stomach are rare due to technical limitations of traditional manometry catheters. Consequently, specific motor patterns and their impact on gastric and small bowe... Read More about Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism.