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Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article
Sebastian, S., Walker, G. J., Kennedy, N. A., Conley, T. E., Patel, K. V., Subramanian, S., Kent, A. J., Segal, J. P., Brookes, M. J., Bhala, N., Gonzalez, H. A., Hicks, L. C., Mehta, S. J., Lamb, C. A., Abdale, S., Abbasi, A., Abusrewil, A., Aghimien, P., Ahmed, S., Ali, A., …Zafar, M. (2021). Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. The Lancet Gastroenterology & Hepatology, 6(4), 271-281. https://doi.org/10.1016/s2468-1253%2821%2900016-9

Background
There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.

Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity (2020)
Journal Article
Gascoyne, L. E., Brookes, M. J., Rathnaiah, M., Zia Ul Haq Katshu, M., Koelewijn, L., Williams, G., Kumar, J., Walters, J. T., Seedat, Z. A., Palaniyappan, L., William Deakin, J., Singh, K. D., Liddle, P. F., & Morris, P. G. (2021). Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity. NeuroImage: Clinical, 29, Article 102524. https://doi.org/10.1016/j.nicl.2020.102524

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrea... Read More about Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity.

Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder (2020)
Journal Article
Packer, M., Hobson, P., Holmes, N., Leggett, J., Glover, P., Brookes, M., Bowtell, R., & Fromhold, T. (2020). Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder. Physical Review Applied, 14(5), Article 054004. https://doi.org/10.1103/PhysRevApplied.14.054004

Magnetic shields that use both active and passive components to enable the generation of a tailored low-field environment are required for many applications in science, engineering, and medical imaging. Until now, accurate field nulling, or field gen... Read More about Optimal Inverse Design of Magnetic Field Profiles in a Magnetically Shielded Cylinder.

Mouth magnetoencephalography: A unique perspective on the human hippocampus (2020)
Journal Article
Tierney, T. M., Levy, A., Barry, D. N., Meyer, S. S., Shigihara, Y., Everatt, M., Mellor, S., Lopez, J. D., Bestmann, S., Holmes, N., Roberts, G., Hill, R. M., Boto, E., Leggett, J., Shah, V., Brookes, M. J., Bowtell, R., Maguire, E. A., & Barnes, G. R. (2021). Mouth magnetoencephalography: A unique perspective on the human hippocampus. NeuroImage, 225, Article 117443. https://doi.org/10.1016/j.neuroimage.2020.117443

Traditional magnetoencephalographic (MEG) brain imaging scanners consist of a rigid sensor array surrounding the head; this means that they are maximally sensitive to superficial brain structures. New technology based on optical pumping means that we... Read More about Mouth magnetoencephalography: A unique perspective on the human hippocampus.

Age-related differences in myeloarchitecture measured at 7 T (2020)
Journal Article
Carradus, A. J., Mougin, O., Hunt, B. A., Tewarie, P. K., Geades, N., Morris, P. G., Brookes, M. J., Gowland, P. A., & Madan, C. R. (2020). Age-related differences in myeloarchitecture measured at 7 T. Neurobiology of Aging, 96, 246-254. https://doi.org/10.1016/j.neurobiolaging.2020.08.009

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the grey matter (GM) of the 78 cortical automated anatomical labelling (AAL) regions of the brain, and the underlying white matter in each region, in... Read More about Age-related differences in myeloarchitecture measured at 7 T.

Quantifying the core deficit in classical schizophrenia (2020)
Journal Article
Rathnaiah, M., Liddle, E., Gascoyne, L., Kumar, J., Zia Ul Haq Katshu, M., Faruqi, C., Kelly, C., Gill, M., Robson, S., Brookes, M., Palaniyappan, L., Morris, P., & Liddle, P. F. (2020). Quantifying the core deficit in classical schizophrenia. Schizophrenia Bulletin Open, 1(1), Article sgaa031. https://doi.org/10.1093/schizbullopen/sgaa031

In the classical descriptions of schizophrenia, Kraepelin and Bleuler recognised disorganization and impoverishment of mental activity as fundamental symptoms. Their classical descriptions also included a tendency to persisting disability. The psycho... Read More about Quantifying the core deficit in classical schizophrenia.

Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system (2020)
Journal Article
Hill, R. M., Boto, E., Rea, M., Holmes, N., Leggett, J., Coles, L. A., Papastavrou, M., Everton, S., Hunt, B. A., Sims, D., Osborne, J., Shah, V., Bowtell, R., & Brookes, M. J. (2020). Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system. NeuroImage, 219, Article 116995. https://doi.org/10.1016/j.neuroimage.2020.116995

© 2020 The Authors Magnetoencephalography (MEG) is a powerful technique for functional neuroimaging, offering a non-invasive window on brain electrophysiology. MEG systems have traditionally been based on cryogenic sensors which detect the small extr... Read More about Multi-channel whole-head OPM-MEG: Helmet design and a comparison with a conventional system.

The role of transient spectral ‘bursts’ in functional connectivity: A magnetoencephalography study (2020)
Journal Article
Seedat, Z. A., Quinn, A. J., Vidaurre, D., Liuzzi, L., Gascoyne, L. E., Hunt, B. A., O’Neill, G. C., Pakenham, D. O., Mullinger, K. J., Morris, P. G., Woolrich, M. W., & Brookes, M. J. (2020). The role of transient spectral ‘bursts’ in functional connectivity: A magnetoencephalography study. NeuroImage, 209, Article 116537. https://doi.org/10.1016/j.neuroimage.2020.116537

A tool for functional brain imaging with lifespan compliance (2019)
Journal Article
Hill, R. M., Boto, E., Holmes, N., Hartley, C., Seedat, Z. A., Leggett, J., Roberts, G., Shah, V., Tierney, T. M., Woolrich, M. W., Stagg, C. J., Barnes, G. R., Bowtell, R. R., Slater, R., & Brookes, M. J. (2019). A tool for functional brain imaging with lifespan compliance. Nature Communications, 10, Article 4785. https://doi.org/10.1038/s41467-019-12486-x

The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelop... Read More about A tool for functional brain imaging with lifespan compliance.

Post-stimulus beta responses are modulated by task duration (2019)
Journal Article
Pakenham, D. O., Quinn, A. J., Fry, A., Francis, S. T., Woolrich, M. W., Brookes, M. J., & Mullinger, K. J. (2020). Post-stimulus beta responses are modulated by task duration. NeuroImage, 206, Article 116288. https://doi.org/10.1016/j.neuroimage.2019.116288

Modulation of beta-band neural oscillations during and following movement is a robust marker of brain function. In particular, the post-movement beta rebound (PMBR), which occurs on movement cessation, has been related to inhibition and connectivity... Read More about Post-stimulus beta responses are modulated by task duration.

Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography (2019)
Journal Article
Holmes, N., Tierney, T. M., Leggett, J., Boto, E., Mellor, S., Roberts, G., Hill, R. M., Shah, V., Barnes, G. R., Brookes, M. J., & Bowtell, R. (2019). Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography. Scientific Reports, 9, Article 14196. https://doi.org/10.1038/s41598-019-50697-w

To allow wearable magnetoencephalography (MEG) recordings to be made on unconstrained subjects the spatially inhomogeneous remnant magnetic field inside the magnetically shielded room (MSR) must be nulled. Previously, a large bi-planar coil system wh... Read More about Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography.

How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity? (2019)
Journal Article
Liuzzi, L., Quinn, A. J., O'Neill, G. C., Woolrich, M. W., Brookes, M. J., Hillebrand, A., & Tewarie, P. (2019). How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?. Frontiers in Neuroscience, 13, Article 797. https://doi.org/10.3389/fnins.2019.00797

Despite advances in the field of dynamic connectivity, fixed sliding window approaches for the detection of fluctuations in functional connectivity are still widely used. The use of conventional connectivity metrics in conjunction with a fixed slidin... Read More about How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?.

Two spatially distinct posterior alpha sources fulfill different functional roles in attention (2019)
Journal Article
Sokoliuk, R., Mayhew, S., Aquino, K., Wilson, R., Brookes, M., Francis, S., Hanslmayr, S., & Mullinger, K. (2019). Two spatially distinct posterior alpha sources fulfill different functional roles in attention. Journal of Neuroscience, 39(36), 7183-7194. https://doi.org/10.1523/jneurosci.1993-18.2019

Directing attention helps extracting relevant information and suppressing distracters. Alpha brain oscillations (8-12Hz) are crucial for this process, with power decreases facilitating processing of important information and power increases inhibitin... Read More about Two spatially distinct posterior alpha sources fulfill different functional roles in attention.

Data‐driven model optimization for optically pumped magnetometer sensor arrays (2019)
Journal Article
Duque‐Muñoz, L., Tierney, T. M., Meyer, S. S., Boto, E., Holmes, N., Roberts, G., Leggett, J., Vargas‐Bonilla, J. F., Bowtell, R., Brookes, M. J., López, J. D., & Barnes, G. R. (2019). Data‐driven model optimization for optically pumped magnetometer sensor arrays. Human Brain Mapping, 40(15), 4357-4369. https://doi.org/10.1002/hbm.24707

© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Optically pumped magnetometers (OPMs) have reached sensitivity levels that make them viable portable alternatives to traditional superconducting technology for magnetoenceph... Read More about Data‐driven model optimization for optically pumped magnetometer sensor arrays.

Towards OPM-MEG in a virtual reality environment (2019)
Journal Article
Roberts, G., Holmes, N., Alexander, N., Boto, E., Leggett, J., Hill, R. M., Shah, V., Rea, M., Vaughan, R., Maguire, E. A., Kessler, K., Beebe, S., Fromhold, M., Barnes, G. R., Bowtell, R., & Brookes, M. J. (2019). Towards OPM-MEG in a virtual reality environment. NeuroImage, 199, 408-417. https://doi.org/10.1016/j.neuroimage.2019.06.010

Virtual reality (VR) provides an immersive environment in which a participant can experience a feeling of presence in a virtual world. Such environments generate strong emotional and physical responses and have been used for wide-ranging applications... Read More about Towards OPM-MEG in a virtual reality environment.

Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography (2019)
Journal Article
Tierney, T. M., Holmes, N., Mellor, S., López, J. D., Roberts, G., Hill, R. M., Boto, E., Leggett, J., Shah, V., Brookes, M. J., Bowtell, R., & Barnes, G. R. (2019). Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography. NeuroImage, 199, 598-608. https://doi.org/10.1016/j.neuroimage.2019.05.063

Optically Pumped Magnetometers (OPMs) have emerged as a viable and wearable alternative to cryogenic, superconducting MEG systems. This new generation of sensors has the advantage of not requiring cryogenic cooling and as a result can be flexibly pla... Read More about Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography.

Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., Sanchez Panchuelo, R. M., Brookes, M. J., Glover, P. M., Wessberg, J., & Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. https://doi.org/10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More about Imaging human cortical responses to intraneural microstimulation using magnetoencephalography.

Updating dynamic noise models with moving magnetoencephalographic (MEG) systems (2019)
Journal Article
Lopez, J. D., Tierney, T. M., Sucerquia, A., Valencia, F., Holmes, N., Mellor, S., Roberts, G., Hill, R., Bowtell, R., Brookes, M. J., & Barnes, G. R. (2019). Updating dynamic noise models with moving magnetoencephalographic (MEG) systems. IEEE Access, 7(1), 10093-10102. https://doi.org/10.1109/access.2019.2891162

Optically pumped magnetometers have opened many possibilities for the study of human brain function using wearable moveable technology. In order to fully exploit this capability, a stable low-field environment at the sensors is required. One way to a... Read More about Updating dynamic noise models with moving magnetoencephalographic (MEG) systems.