All Outputs (2)

Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling (2021)
Journal Article
Hyland, E. M., Webb, A. E., Kennedy, K. F., Gerek Ince, Z. N., Loscher, C. E., & O'Connell, M. J. (2021). Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling. Genome Biology and Evolution, 13(12), Article evab268. https://doi.org/10.1093/gbe/evab268

The TIR domain-containing adapter inducing IFN-β (TRIF) protein is an innate immune system protein that mediates the MyD88-independent toll-like receptor response pathway in mice and humans. Previously, we identified positive selection at seven disti... Read More about Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling.

Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching (2021)
Journal Article
Hopes, T., Norris, K., Agapiou, M., McCarthy, C. G., Lewis, P. A., O'Connell, M. J., …Aspden, J. L. (2022). Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching. Nucleic Acids Research, 50(4), 2240-2257. https://doi.org/10.1093/nar/gkab606

Ribosomes have long been thought of as homogeneous macromolecular machines, but recent evidence suggests they are heterogeneous and could be specialised to regulate translation. Here, we have characterised ribosomal protein heterogeneity across 4 tis... Read More about Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.