All Outputs (3)

A spiral attractor network drives rhythmic locomotion (2017)
Journal Article
Bruno, A. M., Frost, W. N., & Humphries, M. D. (2017). A spiral attractor network drives rhythmic locomotion. eLife, 6, doi:10.7554/elife.27342. ISSN 2050-084X

The joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek the simplest dynamical system that can account for the population activity. By imaging Aplysi... Read More about A spiral attractor network drives rhythmic locomotion.

Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program (2015)
Journal Article
Bruno, A., Frost, W., & Humphries, M. (2015). Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program. Neuron, 86(1), (304-318). doi:10.1016/j.neuron.2015.03.005. ISSN 0896-6273

The neural substrates of motor programs are only well understood for small, dedicated circuits. Here we investigate how a motor program is constructed within a large network. We imaged populations of neurons in the Aplysia pedal ganglion during execu... Read More about Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program.

A new framework for cortico-striatal plasticity: behavioural theory meets In vitro data at the reinforcement-action interface (2015)
Journal Article
Gurney, K. N., Humphries, M. D., & Redgrave, P. (2015). A new framework for cortico-striatal plasticity: behavioural theory meets In vitro data at the reinforcement-action interface. PLoS Biology, 13(1), doi:10.1371/journal.pbio.1002034. ISSN 1544-9173

Operant learning requires that reinforcement signals interact with action representations at a suitable neural interface. Much evidence suggests that this occurs when phasic dopamine, acting as a reinforcement prediction error, gates plasticity at co... Read More about A new framework for cortico-striatal plasticity: behavioural theory meets In vitro data at the reinforcement-action interface.